Granulocytic sarcomas: clinical, diagnostic and therapeutical aspects.
Granulocytic sarcomas: clinical, diagnostic and therapeutical aspects.
复制标题
粒细胞肉瘤：临床、诊断和治疗方面。
DOI：
10.3109/10428199709039023
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发表时间：
1997
影响因子：
2.6
通讯作者：
S. Tura
中科院分区：
文献类型：
--
作者：
Giovanni Martinelli;N. Vianelli;Antonio de Vivo;Paolo F. Ricci;C. Remiddi;N. Testoni;G. Visani;Stefano Baravelli;P. Farabegoli;S. Tura
粒细胞肉瘤（GS）是未成熟骨髓细胞的髓外肿瘤肿块，最常与急性髓细胞白血病相关。我们报告了6例GS患者的诊断、临床和治疗方法，这些患者表现为不同的定位和症状：纵隔肿块伴胸痛、直肠肿瘤伴肠梗阻、膀胱肿块伴急性肾功能衰竭、股四头肌肿瘤伴疼痛、椎体定位伴疼痛和肠肿块伴疼痛。通过骨活检正确诊断GS，肿瘤肿块的免疫组织学评估，在急性髓细胞白血病的一线治疗方案中及时使用活性药物是实现长期缓解的参数。
Granulocytic sarcomas (GS) are extramedullary tumor masses of immature myeloid cells most frequently associated with acute myeloblastic leukemia. We report our diagnostic, clinic and therapeutic approaches in the treatment of 6 patients affected by GS who presented with different localizations and symptoms: mediastinal mass with chest pain, rectal tumor with bowel occlusion, bladder mass with acute kidney failure, quadriceps tumor with pain, vertebral localization with pain and bowel mass with pain, respectively. The correct diagnosis of GS by bone biopsy, the immunohistological evaluation of the tumor masses, the prompt use of active drugs in the first line therapy schedule as for acute myeloblastic leukemia are the parameters for the achievement of the long-term remission.