Increased fasting total homocysteine plasma levels as a risk factor for thromboembolism in children
Increased fasting total homocysteine plasma levels as a risk factor for thromboembolism in children
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DOI：
10.1160/th03-02-0038
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发表时间：
2004-02-01
影响因子：
6.7
通讯作者：
Nowak-Göttl, U
中科院分区：
文献类型：
--
作者：
Kosch, A;Koch, HG;Nowak-Göttl, U
总同型半胱氨酸（tHcy）浓度升高是成人血栓栓塞事件的独立危险因素。在中度高同型半胱氨酸血症的儿童数据稀少。因此，在1995年至2002年期间，我们连续招募了163例首次出现症状性血栓栓塞事件的白色儿科患者和255例健康对照（平均年龄：患者6.4岁，对照组6.6岁，范围：3个月至18岁），并测量了空腹tHcy水平。患者的中位tHcy水平（6.6 pmol/l，范围2.9-20.4 mumol/l）显著高于对照组（5.7 mumol/l，2.0-14.0 mumol/l，p
Elevated total homocysteine (tHcy) concentrations are an independent risk factor for thromboembolic events in adults. In children with moderate hyperhomocysteinemia data are sparse. Therefore, between 1995 and 2002 we consecutively recruited 163 white pediatric patients with a first symptomatic thromboembolic event and 255 healthy controls (mean age: 6.4 years in patients vs. 6.6 years in controls, range: 3 months to 18 years) and measured fasting tHcy levels. Median tHcy levels in patients were significantly higher (6.6 pmol/l, range 2.9-20.4 mumol/l) than in controls (5.7 mumol/l, 2.0-14.0 mumol/l, p