Epidemic asthma and the role of the fungal mold Alternaria alternata
Epidemic asthma and the role of the fungal mold Alternaria alternata
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DOI：
10.1016/j.jaci.2007.04.045
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发表时间：
2007-09-01
影响因子：
14.2
通讯作者：
Nasser, Shuaib M.
中科院分区：
文献类型：
--
作者：
Pulimood, Thomas B.;Corden, Julie M.;Nasser, Shuaib M.
背景：2002年7月29日以后，英国的一次哮喘住院流行与一次雷暴有关。目的：研究雷雨后哮喘流行的原因。方法：对26例雷暴后到剑桥大学医院就诊的哮喘患者进行病例对照研究。对照组为31例夏季季节性哮喘患者。受试者接受了皮肤测试和吸入空气变应原的特异性IgE血清学检查。结果：26例患者中有23例对链格孢菌属具有IgE致敏作用。31名对照组受试者中有11人有在雷雨期间哮喘加重的病史。在这11名对照受试者中，有10人在皮肤测试中对链格孢菌属物种敏感，但在其余20名没有报告雷暴相关哮喘症状的对照组受试者中，只有4人对链格孢菌属物种敏感。对链格孢菌属敏感的人群发生流行性雷暴相关性哮喘的优势比分别为9.31(95%CI，2.305~37.601；P=1143.9)和63.966(95%CI，3.577~3.577；P=0.0008)。
Background: After July 29, 2002, an epidemic of asthma admissions was associated with a thunderstorm in the United Kingdom.Objective: We sought to study the cause of epidemics of asthma associated with thunderstorms.Methods: We performed a case-control study of 26 patients presenting to Cambridge University Hospital with asthma after the thunderstorm. Control subjects were 31 patients with summer seasonal asthma. Subjects underwent skin tests and specific IgE serology to inhaled aeroallergens. Meteorologic and aerobiologic data correlated with asthma admissions were analyzed.Results: Twenty-three of 26 cases had IgE sensitization to Alternaria species. Eleven of 31 control subjects gave a history of asthma exacerbation during thunderstorms. Ten of these 11 control subjects were sensitive to Alternaria species on skin testing, but Alternaria species sensitivity was only identified in 4 of the 20 remaining control subjects who did not report thunderstorm-related asthma symptoms. The odds ratio of having epidemic thunderstorm-related asthma if sensitive to Alternaria species was 9.31 (95% CI, 2.305-37.601; P =.0008) and 63.966 (95% CI, 3.577-1143.9; P