Spirochetemia caused by Borrelia turicatae infection in 3 dogs in Texas
Spirochetemia caused by Borrelia turicatae infection in 3 dogs in Texas
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DOI：
10.1111/j.1939-165x.2007.tb00213.x
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发表时间：
2007-06-01
影响因子：
1.2
通讯作者：
Brillhart, Martin N.
中科院分区：
文献类型：
--
作者：
Whitney, Marlyn S.;Schwan, Tom G.;Brillhart, Martin N.
1999 年 6 月至 2001 年 10 月期间，来自德克萨斯州西北部地区的两只西伯利亚哈士奇犬和一只罗威纳犬被诊断出患有螺旋体血症。临床结果不具特异性；其中两只狗记录了蜱虫暴露。血液学异常包括贫血 (n = 2)、中性粒细胞增多 (n = 2，包括 1 例左移)、淋巴细胞减少 (n = 3)、嗜酸性粒细胞减少 (n = 3) 和血小板减少 (n = 2)。一只贫血狗的库姆斯测试呈阳性。在 1 只狗中，血清蛋白质印迹分析产生了多条斑秃芽孢杆菌裂解物阳性条带，表明螺旋体血症很可能是由斑秃芽孢杆菌感染引起的。从 2 只狗的血液中培养出螺旋体，并通过 DNA 分析将其鉴定为疏螺旋体 (Borrelia turicatae)；其中一只狗的犬埃利希体和伯氏疏螺旋体血清呈阳性。在 2 例病例中，样本采集后立即制备的血涂片中的螺旋体血症比 EDTA 血液制备的涂片中的螺旋体血症更为明显。两只狗接受强力霉素治疗后康复； 1 只狗尽管经过治疗，但临床症状却有所下降，并被安乐死。 turicatae 伯氏疏螺旋体是人类蜱传（地方性）回归热的病原体，与莱姆病的病原体伯氏伯氏疏螺旋体不同；然而，可能会发生血清学交叉反应。 B turicatae 由软蜱（Ornithodoros turicata）传播，患有螺旋体血症并可能接触蜱媒介的狗应考虑感染。
Spirochetemia was diagnosed in 2 Siberian Huskies and a Rottweiler from the northwestern region of Texas between June 1999 and October 2001. Clinical findings were nonspecific; tick exposure was documented in 2 of the dogs. Hematologic abnormalities included anemia (n = 2), neutrophilia (n = 2, including 1 with a left shift), lymphopenia (n = 3), eosinopenia (n = 3), and thrombocytopenia (n = 2). One anemic dog had a positive Coombs' test. In 1 dog, Western blot analysis of serum yielded multiple positive bands with B turicatae lysate, indicating the spirochetemia most likely was due to B turicatae infection. In 2 dogs, spirochetes were cultured from the blood and identified using DNA analysis as Borrelia turicatae; 1 of these dogs also was seropositive for Ehrlichia canis and B burgdorferi. In 2 cases, spirochetemia was more prominent in blood smears prepared immediately after sample collection than in smears prepared from EDTA blood. Two dogs recovered with doxycycline treatment; 1 dog declined clinically despite treatment and was euthanized. B turicatae is the agent of tick-borne ( endemic) relapsing fever in humans and is distinct from B burgdorferi, the agent of Lyme disease; however, serologic cross-reactivity may occur. B turicatae is transmitted by the soft tick, Ornithodoros turicata, and infection should be considered in dogs with spirochetemia and possible exposure to the tick vector.