Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach
Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach
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DOI：
10.3390/pharmaceutics12070653
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发表时间：
2020-07-01
期刊：
影响因子：
5.4
通讯作者：
Leyssens, Tom
中科院分区：
文献类型：
--
作者：
Buol, Xavier;Robeyns, Koen;Leyssens, Tom
在这项工作中，我们是第一个确定13个共晶体的奈非西坦，一个穷人的水溶性益智化合物。其中三种是用生物相容性共结晶剂柠檬酸、草酸和氯化锌获得的。对后者进行了充分的结构和物理表征，并将溶解度、溶出速率和稳定性与初始活性药物成分（API）进行了比较。
In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and stability were compared to that of the initial Active Pharmaceutical Ingredient (API).