AROUSAL STATE VS TEMPERATURE EFFECTS ON NEURONAL-ACTIVITY IN SUBCOERULEUS AREA
AROUSAL STATE VS TEMPERATURE EFFECTS ON NEURONAL-ACTIVITY IN SUBCOERULEUS AREA
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DOI：
10.1152/ajpregu.1989.256.4.r840
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发表时间：
1989-04-01
影响因子：
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通讯作者：
HELLER, HC
中科院分区：
文献类型：
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作者：
GRAHN, DA;RADEKE, CM;HELLER, HC
据信，热传入神经元在蓝斑下区（SC）中形成突触。为了评估唤醒状态对热传入信息处理的影响，我们记录了未麻醉大鼠的SC单位活动。在唤醒状态下，没有观察到对环境温度变化的反应，但85%的单位在唤醒状态改变时显著改变了它们的放电率。我们复制了以前的实验麻醉动物的基础上归因于热传入功能的SC。此外，我们监测脑电图（EEG）活动。在轻度麻醉的大鼠中，可以定义五种不同的EGG状态，并且动物的温度曲线是EEG状态的主要决定因素。在EEG状态下没有观察到热反应，但78%的单位显着改变了与EEG模式变化同步的放电率。对伤害性刺激的瞬时反应也反映在EEG模式和单单位活动中。我们的结论是，SC的单单位活动是不具体的热信息的处理，但与EEG活动，这反过来又是由各种因素，包括热刺激。
It is believed that thermoafferent neurons synapse in the subcoeruleus area (SC). To assess the effect of arousal state on thermoafferent information processing, we recorded SC unit activity in unanesthetized rats. No responses to changes in ambient temperature were observed within an arousal state, but 85% of the units dramatically altered their firing rates as the arousal state changed. We replicated previous experiments on anesthetized animals which were the basis for ascribing thermoafferent function to the SC. Additionally, we monitored electroencephalographic (EEG) activity. In lightly anesthetized rats, five distinct EGG states could be defined, and the temperature profile of the animal was a primary determinant of the EEG state. No thermoresponses were observed within an EEG state, but 78% of the units dramatically altered their firing rates in synchrony with EEG pattern changes. Transient responses to noxious stimuli were also reflected in both the EEG patterns and single-unit activity. We conclude that SC single-unit activity is not specific for processing of thermal information but is correlated with EEG activity, which in turn is determined by a variety of factors including thermal stimuli.