Maternal smoking during pregnancy and the risk of childhood cancer [letter]
Maternal smoking during pregnancy and the risk of childhood cancer [letter]
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母亲在怀孕期间吸烟与儿童患癌症的风险[信件]
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
Li Fp
中科院分区：
文献类型：
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作者：
Li Fp
Stjernfeldt博士及其同事报告说，与瑞典青少年糖尿病患者相比，患有癌症的儿童在子宫内暴露于母亲吸烟的频率更高。母亲吸烟与患3种具有不同病因（流行病学）特征的肿瘤的风险加倍相关，即肾肿瘤、非霍奇金淋巴瘤和急性淋巴细胞白血病（ALL）。这一发现是基于小的数字和条件的糖尿病患者是一个适当的控制组。280名瑞典癌症儿童的母亲在怀孕期间吸烟的频率与我们对436名美国儿童癌症病例的访谈数据进行了比较（表）。我们没有检查吸烟的“剂量”，比较的基础是任何报告的母亲吸烟。2个系列中所有合并肿瘤的暴露率相似，但特定肿瘤类型不一致。与美国相比，瑞典的母亲吸烟在患肾母细胞瘤、非霍奇金淋巴瘤和急性淋巴细胞白血病的儿童中更为常见。霍奇金斯病的情况则相反。当两个系列合并时，母亲吸烟与这些类型肿瘤的过度风险无关。怀孕期间吸烟肯定会伤害发育中的胎儿，但它作为儿童癌症原因的作用仍然不确定。(full（正文）
Dr. Stjernfeldt and colleagues reported a higher frequency of in-utero exposure to maternal smoking among children with cancer as compared with juvenile diabetics in Sweden. Maternal smoking was associated with a doubled risk of 3 tumors with seemingly diverse etiological (epidemiological) features--namely kidney tumor non-Hodgkin lymphoma and acute lymphoblastic leukemia (ALL). The finding is based on small numbers and conditional on diabetics being an appropriate control group. The frequency of maternal cigarette smoking during gestation of the 280 Swedish children with cancer has been compared with our interview data for 436 childhood cancer cases in the US (table). We did not examine smoking "dose" and the basis of the comparison is any reported maternal smoking. Exposure rates in the 2 series are similar for all tumors combined but discrepant specific tumor types. As compared with the US exposure to maternal smoking in Sweden was much more frequent among children with Wilms tumor non-Hodgkin lymphoma and ALL. The opposite was reported for Hodgkins diseases. When the 2 series are merged maternal smoking is not associated with excess risk of these types of tumor. Smoking during pregnancy can certainly harm the developing fetus but its role as cause of childhood cancers remains uncertain. (full text)