Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases.
Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases.
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DOI：
10.3389/fimmu.2017.01058
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发表时间：
2017
影响因子：
7.3
通讯作者：
Atanasov AG
中科院分区：
文献类型：
--
作者：
Mozos I;Malainer C;Horbańczuk J;Gug C;Stoian D;Luca CT;Atanasov AG
动脉僵硬预示着心血管事件的风险增加。炎症在大动脉硬化中起主要作用，与动脉粥样硬化、动脉硬化、内皮功能障碍、平滑肌细胞迁移、血管钙化、金属蛋白酶活性增加、细胞外基质降解、氧化应激、弹性溶解和胶原蛋白降解有关。本文结合最新的临床和实验研究，综述了炎症与动脉僵硬之间相互作用的主要机制，以及与动脉僵硬增加相关的最常见炎症标志物。多种研究显示，动脉僵硬程度与炎症标志物（如白细胞计数、中性粒细胞/淋巴细胞比率、粘附分子、纤维蛋白原、c反应蛋白、细胞因子、microrna和环氧化酶-2）在多种疾病（如代谢综合征、糖尿病、冠心病、外周动脉疾病、恶性疾病和风湿性疾病、多囊肾病、肾移植、肾移植、肾移植和肾移植）患者中的显著相关性。家族性地中海热和口腔感染，以及子痫前期或绝经后妇女。有强有力的证据表明，炎症在动脉僵硬的发展中起着重要的作用，至少在一定程度上是可逆的，炎症标志物可能是临床实践中评估心血管风险的有用的附加工具。动脉僵硬度和炎症标志物的联合评估可以改善心血管风险的非侵入性评估，从而可以选择高危患者进行预防性治疗或更定期的医学检查。未来祛炎疗法的发展可能针对促炎机制。
Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vascular calcification, increased activity of metalloproteinases, extracellular matrix degradation, oxidative stress, elastolysis, and degradation of collagen. The present paper reviews main mechanisms explaining the crosstalk between inflammation and arterial stiffness and the most common inflammatory markers associated with increased arterial stiffness, considering the most recent clinical and experimental studies. Diverse studies revealed significant correlations between the severity of arterial stiffness and inflammatory markers, such as white blood cell count, neutrophil/lymphocyte ratio, adhesion molecules, fibrinogen, C-reactive protein, cytokines, microRNAs, and cyclooxygenase-2, in patients with a broad variety of diseases, such as metabolic syndrome, diabetes, coronary heart disease, peripheral arterial disease, malignant and rheumatic disorders, polycystic kidney disease, renal transplant, familial Mediterranean fever, and oral infections, and in women with preeclampsia or after menopause. There is strong evidence that inflammation plays an important and, at least, partly reversible role in the development of arterial stiffness, and inflammatory markers may be useful additional tools in the assessment of the cardiovascular risk in clinical practice. Combined assessment of arterial stiffness and inflammatory markers may improve non-invasive assessment of cardiovascular risk, enabling selection of high-risk patients for prophylactic treatment or more regular medical examination. Development of future destiffening therapies may target pro-inflammatory mechanisms.