INVOLUCRIN EXPRESSION IN NORMAL AND NEOPLASTIC HUMAN-SKIN - A MARKER FOR KERATINOCYTE DIFFERENTIATION
INVOLUCRIN EXPRESSION IN NORMAL AND NEOPLASTIC HUMAN-SKIN - A MARKER FOR KERATINOCYTE DIFFERENTIATION
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DOI：
10.1111/1523-1747.ep12260945
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发表时间：
1984-01-01
影响因子：
6.5
通讯作者：
PINKUS, GS
中科院分区：
文献类型：
--
作者：
MURPHY, GF;FLYNN, TC;PINKUS, GS
外皮蛋白是最近公认的成熟鳞状上皮细胞的结构成分。使用免疫过氧化物酶技术检查正常皮肤和各种表皮增生和肿瘤中的外皮蛋白表达，以确定这些病变内是否存在独特的染色模式。观察到四种反应模式：正常表皮上 1/3 和表皮增生和良性肿瘤的角质形成细胞典型的弥漫性细胞内染色；细胞边界染色，主要见于良性表皮肿瘤；原位鳞状细胞癌的斑片状染色特征；良性和肿瘤性基底样上皮没有染色。鳞状细胞癌的侵袭性巢的外皮蛋白反应性呈阴性，而角化棘皮瘤基底部的上皮的假性侵袭性舌呈局灶性阳性。外皮蛋白的免疫过氧化物酶染色可用于区分某些良性和恶性表皮肿瘤，以及了解影响角质形成细胞的增殖过程的成熟和动力学的改变。
Involucrin is a recently recognized structural component of mature squamous epithelial cells. Involucrin expression was examined using an immunoperoxidase technique in normal skin and in a variety of epidermal hyperplasias and neoplasms to determine whether distinctive staining patterns existed within these lesions. Four patterns of reactivity were observed: diffuse intracellular staining typical of keratinocytes of the upper 1/3 of normal epidermis and epidermal hyperplasias and benign neoplasms; staining at cell borders, seen principally in benign epidermal neoplasms; patchy staining characteristic of squamous cell carcinoma in situ; and absence of staining in benign and neoplastic basaloid epithelium. Invasive nests of squamous cell carcinomas were negative for involucrin reactivity, whereas pseudoinvasive tongues of epithelium at the bases of keratoacanthomas were focally positive. Immunoperoxidase staining for involucrin may be useful in distinguishing certain benign from malignant epidermal neoplasms as well as in understanding the altered maturation and kinetics of proliferative processes afflicting keratinocytes.