Human neutrophil calprotectin reduces the susceptibility of Borrelia burgdorferi to penicillin.
Human neutrophil calprotectin reduces the susceptibility of Borrelia burgdorferi to penicillin.
复制标题
人中性粒细胞钙卫蛋白降低伯氏疏螺旋体对青霉素的敏感性。
DOI：
10.1128/iai.74.4.2468-2472.2006
复制
发表时间：
2006
影响因子：
3.1
通讯作者：
Malawista,StephenE
中科院分区：
文献类型：
--
作者：
Montgomery,RuthR;Schreck,Kimberly;Wang,Xiaomei;Malawista,StephenE
莱姆病螺旋体是莱姆病的螺旋体病原体，容易被多种多形核白细胞（PMN）成分杀死。有些对代谢活性B最有效。burgdorferi。丰富的中性粒细胞胞质蛋白钙卫蛋白，升高10- 100倍，炎症，抑制螺旋体的生长，通过螯合的必需阳离子，锌。由于一些治疗性抗生素的作用取决于细菌的分裂，我们研究了螺旋体在钙卫蛋白中的抗生素敏感性。在生理钙卫蛋白中，B.治疗剂量的青霉素G不能消除伯氏螺旋体;相反，强力霉素是有效的。钙卫蛋白可改变炎症部位螺旋体的清除。
Borrelia burgdorferi, the spirochetal agent of Lyme disease, is susceptible to killing by a variety of polymorphonuclear leukocyte (PMN) components. Some are most effective against metabolically activeB. burgdorferi. The abundant PMN cytoplasmic protein calprotectin, elevated 10- to 100-fold in inflammation, inhibits the growth of spirochetes through chelation of the essential cation, Zn. Since the action of some therapeutic antibiotics depends on bacterial division, we investigated the antibiotic sensitivities of spirochetes in calprotectin. In physiologic calprotectin,B. burgdorferiis not eliminated by therapeutic doses of penicillin G; in contrast, doxycycline is effective. Calprotectin may modify the clearance of spirochetes at sites of inflammation.