FSH AND LH PITUITARY RESERVE AND OUTPUT IN THE POST-MENOPAUSE
FSH AND LH PITUITARY RESERVE AND OUTPUT IN THE POST-MENOPAUSE
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DOI：
10.1016/0378-5122(80)90059-6
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发表时间：
1980-01-01
期刊：
影响因子：
4.9
通讯作者：
SCHOLLER, R
中科院分区：
文献类型：
--
作者：
GELLER, S;SCHOLLER, R
卵泡刺激素[FSH]和黄体生成素[LH]的基础水平和它们在luliberin [LH-RH]给药后的累积反应与绝经后患者的血浆雌二醇水平一起被测定沿着。研究了绝经后患者（89例）。根据绝经后的时间将她们分为4组。组I为绝经后2年以下，组II为绝经后2-5年，组III为绝经后5-10年，组IV为绝经后10年或以上。在静脉推注100 μ g LH-RH之前和注射后不同的时间间隔抽取血液。测定FSH、LH和血浆雌二醇。通过面积测量法计算LH-RH后FSH和LH累积反应[CR]和总累积反应（TCR），其定义为描记与通过基底水平（CR）或X轴（TCR）绘制的水平线之间的表面积。FSH的基础水平往往随着年龄的增长而增加，在3岁组达到最大值，此后下降。类似的趋势，虽然不那么直言不讳，被认为是在LH基础水平。LH-RH后FSH累积反应（用平均增量（Δ）表示，维持在2小时的测试持续时间）显着低于相应的FSH基础水平，并似乎在整个绝经后保持在相同的水平。LH-RH后LH累积反应，以相同的方式表示，与相应的LH基础水平相比。在较年轻的年龄组中最高，与仍然可观的雌二醇水平相关，并在随后的年龄组中下降。LH-TCR和LH-TCR：FSH-TCR比值显示出与LH累积应答相似的趋势。这种特殊的模式，显然与雌二醇水平有关。
Follicle stimulating hormone [FSH] and luteinizing hormone [LH] basal levels and their cumulative responses following luliberin [LH-RH] administration were determined along with plasma estradiol levels in postmenopausal patients. Postmenopausal patients (89) were studied. They were divided into 4 groups according to the time elapsed since their menopause. Group I being less than 2 yr postmenopausal, group II from 2-5 yr, group III 5-10 yr and group IV 10 yr or more postmenopausal. Blood was drawn before a bolus i.v. injection of 100 .mu.g of LH-RH was given and at different time intervals after the injection. FSH, LH and plasma estradiol were assayed. FSH and LH cumulative responses [CR] after LH-RH and total cumulative responses (TCR), as defined by the surface area comprised between the tracing and a horizontal line drawn through the basal level (CR) or the X-axis (TCR) were calculated by planimetry. The basal levels of FSH tend to increase with age, with a maximum in the 3rd age group and a decline thereafter. A similar trend, though less outspoken, was seen in the LH basal levels. FSH cumulative responses after LH-RH (as expressed by the mean increment (.DELTA.), maintained over the 2 h duration of the test) were significantly lower than the corresponding FSH basal levels and appeared to remain at the same level throughout postmenopause. LH cumulative responses after LH-RH, expressed in the same way, compared with corresponding LH basal levels. They were highest in the younger age group, associated with still appreciable estradiol levels and declined in the subsequent age groups. LH-TCR and the LH-TCR:FSH-TCR ratio showed a similar trend as LH cumulative responses. This peculiar pattern, is evidently related to estradiol levels.