Effects of chronic ibogaine treatment on cerebellar Purkinje cells in the rat.
Effects of chronic ibogaine treatment on cerebellar Purkinje cells in the rat.
复制标题
长期伊博加因治疗对大鼠小脑浦肯野细胞的影响。
DOI：
10.1016/s0006-8993(97)00365-x
复制
发表时间：
1997
期刊：
影响因子：
2.9
通讯作者：
Winter,JC
中科院分区：
文献类型：
--
作者：
Helsley,S;Dlugos,CA;Pentney,RJ;Rabin,RA;Winter,JC
本研究评估了伊波替尼对雄性Fischer 344大鼠小脑浦肯野细胞的慢性毒性。行为活性剂量的伊波替尼（10 mg/kg，i. p.）每隔一天对一组6名受试者给药，持续60天，而对照组接受等体积的盐水（1 ml/kg）。浦肯野细胞数量的估计值使用光学解剖器/分馏器技术确定。伊波替尼组（243764[±32766]）和对照组（230813[±16670]）的浦肯野细胞数量无显著差异。
The present investigation assessed the chronic toxicity of ibogaine on cerebellar Purkinje cells in male Fischer 344 rats. A behaviorally active dose of ibogaine (10 mg/kg, i.p.) was administered to a group of six subjects every other day for 60 days while the control group received an equivalent volume of saline (1 ml/kg). Estimates of Purkinje cell number were determined using the optical dissector/fractionator technique. No significant differences in Purkinje cell number were observed between the ibogaine (243764[±32766]) and control groups (230813[±16670]).