Benzylation of hydroxy groups with tertiary amine as a base
Benzylation of hydroxy groups with tertiary amine as a base
复制标题
DOI：
10.1016/j.tet.2011.10.016
复制
发表时间：
2012-01-07
期刊：
影响因子：
2.1
通讯作者：
Maki, Toshihide
中科院分区：
文献类型：
--
作者：
Gathirwa, Jeremiah W.;Maki, Toshihide
描述了在叔胺存在下羟基的苄基化。在二异丙基乙胺存在下，醇和苄基卤的混合物以良好至优异的产率提供相应的苄基醚。观察到无溶剂条件的重要性。该反应即使在150 ℃的反应温度下也显示出对包括苯甲酸酯在内的许多官能团的高耐受性。碘化钠被发现是一种有效的催化剂，以加速反应。(C)2011爱思唯尔有限公司保留所有权利。
The benzylation of hydroxy groups in the presence of tertiary amines is described. A mixture of an alcohol and a benzyl halide afforded the corresponding benzyl ether in good to excellent yields in the presence of diisopropylethylamine. The importance of solventless conditions was observed. The reaction showed high tolerance to many functional groups including benzoate, even at a reaction temperature of 150 degrees C. Sodium iodide was found to be an efficient catalyst to accelerate the reaction. (C) 2011 Elsevier Ltd. All rights reserved.