Histopathogenesis of spontaneous periodontal disease in conventional rats. III. The mononuclear cell infiltrate and cytoplasmic changes in associated fibroblasts.
Histopathogenesis of spontaneous periodontal disease in conventional rats. III. The mononuclear cell infiltrate and cytoplasmic changes in associated fibroblasts.
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常规大鼠自发性牙周病的组织病理学。
DOI：
10.1111/j.1600-0765.1980.tb00271.x
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发表时间：
1980
影响因子：
3.5
通讯作者：
M. Cho
中科院分区：
文献类型：
--
作者：
P. Garant;M. Cho
将喂食正常实验室饲料的大鼠与喂食高糖饲料的大鼠的牙龈炎和牙周炎病变的发展进行了比较（Keyes'diet 2000）。上颌第一牙间区中远端切片的组织计量学分析显示，饮食2000组炎症结缔组织（ICT）面积增加更快。在2000饮食组中，牙周炎病变与活跃骨吸收的发生率更高。对ICT细胞类型的分析显示，两种饮食组之间没有统计学上的显著差异。然而，当将两种饮食组牙周炎病变中存在的各种细胞类型的百分比与两种饮食组牙周炎病变中存在的细胞类型百分比进行比较时，发现在牙周炎病变的ICT中存在两种大的单核细胞的统计显著增加。在牙周炎病变中内皮细胞的数量也有统计学意义的减少。在超微结构水平上，牙龈上皮下可见成纤维细胞病理改变和胶原纤维减少。上皮附着体下的骨水泥表面的剥蚀变得越来越严重，并先于上皮沿骨水泥表面的迁移。
The development of gingivitis and periodontitis lesions in rats fed a normal laboratory chow diet was compared to that which occurred in rats fed a high sucrose diet (Keyes'diet 2000). Histometric analysis of mesio-distal sections through the 1st maxillary interdetal area revealed that the area of inflamed connectve tissue(ICT) increased more rapidly in the diet 2000 group. A greater incidence of periodontitis lesions with active bone resorption was noted in the diet 2000 group. Analysis of cell types in the ICT revealed no statistically significant differences between the two diet groups. However when the percent age of various cell types present in the periodontitis lesions of both dietary groups were compared to the percentage of the cell typed present in the periodontitis lesions of both dietary groups were compared to the percentage of the cell typed persent in gingivitis lesions a statistically significant increase in both large mononuclear cells was found to exist in the ICT of the Periodontitis lisions. A statistically significant decrease in the number of endothelial cells was also observed in periodontitis lesions. At the ultrastructural level cytopathologic alterations of fibroblasts and decreased collagen fibers were noted beneath the gingival epithelium. Denudation of the cemental surface beneath the epithelial attachment became progressively more severe and preceded the migration of the epithelium along the cemental surface.