Paraquat accumulation: tissue and species specificity.
Paraquat accumulation: tissue and species specificity.
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百草枯积累：组织和物种特异性。
DOI：
10.1016/0006-2952(76)90344-0
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发表时间：
1976
影响因子：
5.8
通讯作者：
I. Wyatt
中科院分区：
文献类型：
--
作者：
M. Rose;E. Lock;L. L. Smith;I. Wyatt
在体外对大鼠组织进行了检测，以确定它们是否能够积累百草枯或敌草快，使其浓度超过培养介质中的浓度。浓度为10 - 6 M。肺切片能够积累百草枯，其浓度几乎是培养基浓度的十倍。在两小时的时间内，将脑切片的浓度提高到培养基的两倍。无论是肺切片还是脑切片，敌草快在培养基中的浓度为10− 6 M时都没有显著积累。百草枯在脑切片中的蓄积，与肺切片中的蓄积一样，已被证明具有能量依赖性。检查的其他器官显示，百草枯或敌草快的积累能力很小，如果有的话。狗的肺切片猴和兔也显示出具有体外积累百草枯的能力。大鼠口服百草枯后。30小时后，肺中的百草枯浓度随着时间的推移而增加，达到血浆浓度的6倍。除肾脏外，其他器官中的百草枯浓度没有达到相同的程度。在整个研究期间，口服百草枯和敌草快后肾脏中的浓度都很高。是的因此，这表明百草枯对肺的明显选择性与蓄积过程有关。
Rat tissues have been examinedin vitrofor their ability to accumulate paraquat or diquat to concentrations in excess of those present in the incubation medium. With a concentration of 10−6M. lung slices were able to accumulate paraquat to concentrations nearly ten times that of the medium. and brain slices to concentrations double that of the medium, over a period of two hours. Neither slices of lung nor brain accumulated diquat significantly from a concentration in the medium of 10−6M. The accumulation of paraquat by brain slices, like that of lung slices, has been shown to he energy-dependent. Other organs examined showed little, if any, ability to accumulate either paraquat or diquat. Lung slices from dog. monkey and rabbit have also been shown to possess the ability to accumulate paraquatin vitro. After oral dosing of paraquat to rats. the lung concentration increased with time to six times that of the plasma after 30 hr. Other organs, with the exception of the kidney, did not concentrate paraquat to the same extent. Kidney concentrations after oral dosing of both paraquat and diquat were high throughout the period of time studied. It is. therefore, suggested that the apparent selectivity exhibited by paraquat for the lung is associated with the accumulation process.