Corpus callosum size and neuropsychologic impairment in adolescents who were born preterm
Corpus callosum size and neuropsychologic impairment in adolescents who were born preterm
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DOI：
10.1177/08830738060210050801
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发表时间：
2006-05-01
影响因子：
1.9
通讯作者：
Botet, Francesc
中科院分区：
文献类型：
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作者：
Caldu, Xavier;Narberhaus, Ana;Botet, Francesc
早产与大脑异常有关，这可能是认知能力较差的原因。本研究的目的是探讨早产青少年胼胝体减少与神经心理表现之间的相关性。25例妊娠33周前出生的受试者与25例足月出生的年龄、性别和社会文化地位相似的受试者进行了比较。所有受试者均接受磁共振成像和神经心理学检查。早产儿在整体认知功能、言语记忆和言语流畅性方面的表现比对照组差。胼胝体的测量结果显示，主要是由于在压部，后中体，和胼胝体变薄全球减少。胼胝体的大小与胎龄、韦氏智商和记忆能力显著相关。这些结果表明，婴儿期大脑的生长并不能补偿胼胝体的减少，这种减少反映了神经心理学的缺陷。认知障碍可能是由于纤维损伤，特别是有髓纤维，导致复杂的神经元间连接缺乏而引起的。
Prematurity is associated with cerebral abnormalities that might account for poorer cognitive performance. The aim of our study was to investigate the correlations between corpus callosum reductions and neuropsychologic performance in adolescents who were born preterm. Twenty-five subjects born before 33 weeks' gestation were compared with 25 subjects born at term and of similar age, gender, and sociocultural status. All subjects underwent magnetic resonance imaging and neuropsychologic examinations. Premature subjects performed worse than controls in global cognitive functioning, verbal memory, and verbal fluency. Corpus callosum measurements showed a global reduction owing mainly to thinning in the splenium, posterior midbody, and genu. Corpus callosum size significantly correlated with gestational age, Wechsler Performance IQ, and memory performance. These results suggest that cerebral growth during infancy does not compensate for corpus callosum reduction and that this reduction reflects neuropsychologic deficit. The cognitive impairment can arise from the paucity of the complex interneuronal connections owing to fiber damage, particularly myelinated fibers.