Validation of an efficient two-dimensional model for dense suspensions of red blood cells
Validation of an efficient two-dimensional model for dense suspensions of red blood cells
复制标题
红细胞密集悬浮液的高效二维模型的验证
DOI：
10.1142/s0129183114410058
复制
发表时间：
2014
影响因子：
1.9
通讯作者：
A. G. Hoekstra
中科院分区：
文献类型：
--
作者：
L. Mountrakis;E. Lorenz;A. G. Hoekstra
血液的许多流变学性质，沿着血细胞的运输性质，可以通过通过其主要成分红细胞（RBC）和血浆对血液进行建模来捕获。在目前的工作中，我们提出了一个完全解决的血液悬浮液流动的二维模型，采用离散元模型（DEM）的红细胞和耦合到格子玻尔兹曼方法（LBM）流体求解器使用浸没边界法（IBM）。我们确定了一个有效的计算减少介观表示的细胞和流动，仍然能够恢复基本的物理和生理现象。我们的模型被发现同意定量与实验结果。恢复了Fahraeus-Lindqvist效应和剪切变稀，而无细胞层（CFL）的厚度与观测结果相匹配。此外，我们还研究了单个红细胞在剪切流中沿着从翻滚到坦克踩踏的过渡过程中的坦克踩踏频率，也与实验数据相匹配。
Many rheological properties of blood, along with transport properties of blood cells can be captured by means of modeling blood through its main constituents, red blood cells (RBCs) and plasma. In the current work, we present a fully resolved two-dimensional model for blood suspension flow, employing a discrete element model (DEM) for RBCs and coupling it to a lattice Boltzmann method (LBM) fluid solver using the immersed boundary method (IBM). We identify an efficient computationally reduced mesoscopic representation of cells and flow, still able to recover essential physics and physiological phenomena. Our model is found to agree quantitatively with experimental findings. The Fahraeus–Lindqvist effect and shear thinning is recovered, while the thickness of the cell-free layer (CFL) matches the observations. In addition, we investigate the tank-treading frequency of a single RBC in shear flow along with the transition from tumbling to tank-treading, also matching experimental data.
影响因子：
7.5
作者：
D. Mori;K. Yano;K. Tsubota;T. Ishikawa;S. Wada and T. Yamaguchi
通讯作者：
S. Wada and T. Yamaguchi