Occupational exposures and risk of female infertility
Occupational exposures and risk of female infertility
复制标题
DOI：
10.1097/00043764-199702000-00011
复制
发表时间：
1997-02-01
影响因子：
3.2
通讯作者：
Fuortes, L
中科院分区：
文献类型：
--
作者：
Smith, EM;HammondsEhlers, M;Fuortes, L
这项研究调查了281名女性和216名有生育能力的女性中职业性化学和辐射暴露与医学诊断不孕风险的关系。在对年龄和病例/参照确定之前发生的暴露进行调整后，接触挥发性有机溶剂(优势比[OR]，1.74；95%可信区间[CI]，1.11至2.71)、化学粉尘(OR，2.66；CI，1.17至6.05)、杀虫剂(OR，3.02；CI，1.10至8.29)和视频显示终端(OR，2.21，CI，1.22至4.01)的妇女不孕风险增加。在医学诊断的不孕症原因中，接触溶剂(OR，1.75；CI，1.03至2.98)、粉尘(OR，3.00；CI，1.19至7.52)或杀虫剂(OR，3.82；1.28至11.42)的女性，与排卵因素相关的调整后风险增加。溶剂和粉尘也与输卵管因素不孕症(溶剂：OR，1.95；CI：1.08至3.52；粉尘：OR，2.87；CI，1.05至7.88)和子宫内膜异位症(溶剂：OR，2.13；CI，0.96至4.72；粉尘：OR，3.63；CI，0.99至13.28)的高风险相关。在被诊断为子宫内膜异位症(OR，3.69；CI，1.50至9.13)和宫颈因素不孕症(OR，2.65；CI，0.99至7.12)的女性中，视频显示终端暴露的可能性更大。结果表明，在医学确诊的女性中，各种职业化学物质暴露可能会对生育力产生不利影响。
This study examined the association between occupational chemical and radiation exposures and risk of medically diagnosed infertility in 281 women compared with 216 fertile women. After adjustment for age and exposures that occurred before case/referent ascertainment, there was an increased risk of infertility among those women exposed to volatile organic solvents (odds ratio [OR], 1.74; 95% confidence interval [CI], 1.11 to 2.71), chemical dusts (OR, 2.66; CI, 1.17 to 6.05), pesticides (OR, 3.02; CI, 1.10 to 8.29), and video display terminals (OR, 2.21, CI, 1.22 to 4.01). Among the medically diagnosed causes of infertility, the adjusted risk associated with having an ovulatory factor increased among those women exposed to solvents (OR, 1.75; CI, 1.03 to 2.98), dusts (OR, 3.00; CI, 1.19 to 7.52), or pesticides (OR, 3.82; 1.28 to 11.42). Solvents and dusts also were associated with a higher risk of tubal-factor infertility (solvents: OR, 1.95; CI, 1.08 to 3.52; dusts: OR, 2.87; CI, 1.05 to 7.88) and endometriosis (solvents: OR, 2.13; CI, 0.96 to 4.72; dusts: OR, 3.63; CI, 0.99 to 13.28). Video display terminal exposure was more likely to be found among those women diagnosed with endometriosis (OR, 3.69; CI, 1.50 to 9.13) and cervical-factor infertility (OR, 2.65; CI, 0.99 to 7.12). Results suggest that among women with a medically confirmed diagnosis, fertility may be adversely affected by a variety of occupational chemical exposures.