Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss
Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss
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DOI：
10.1210/jc.85.9.3338
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发表时间：
2000-09-01
影响因子：
5.8
通讯作者：
Hainque, B
中科院分区：
文献类型：
--
作者：
Bastard, JP;Jardel, C;Hainque, B
这项研究的目的是研究脂肪细胞因子在肥胖相关胰岛素抵抗中的潜在作用。为此，我们比较了：1）白介素6（IL-6）的血清浓度，肿瘤坏死因子α（TNFα）和八个健康的瘦对照雌性中的瘦素和瘦素，而在没有（n = 14）的Android肥胖女性中（n = 14），以及具有（n = 7）2型糖尿病； 2）在Avery低热量饮食（VLCD）3周之前和之后，在14位肥胖的非糖尿病妇女（VLCD）之前和之后，这些细胞因子的水平均在血清和SC脂肪组织中的水平。与瘦肉对照相比，肥胖的非糖尿病患者和糖尿病患者具有更大的胰岛素耐药性，并且瘦素，IL-6，TNFα和C反应蛋白的值增加。在整个组中，IL-6值与评估胰岛素抗性的参数比瘦素或TNFα值更紧密相关。 VLCD导致体重减轻和体内脂肪质量降低（类似于3公斤）。胰岛素敏感性得到了提高，而浴血清和脂肪组织TNFα水平无显着变化。相反，VLCD在脂肪组织和血清中诱导IL-6和瘦素水平的显着降低。这些结果表明，至于瘦素，循环IL-6浓度至少部分反映了脂肪组织的产生。体重减轻后的产生和血清浓度降低可能在这些患者中观察到的胰岛素的敏感性中起作用。
The aim of this study was to investigate the potential role of adipose cytokines in the obesity-associated insulin resistance. To that end, we compared: 1) serum concentrations of interleukin 6 (IL-6), tumor necrosis factor alpha(TNF alpha), and leptin in eight healthy lean control females and in android obese female without (n = 14) and with (n = 7) type 2 diabetes; and 2) the levels of these cytokines both in serum and in sc adipose tissue in the 14 obese nondiabetic women before and after 3 weeks of avery low-calorie diet (VLCD). As compared with lean controls, obese nondiabetic and diabetic patients were more insulin resistant and presented increased values for leptin, IL-6, TNF alpha, and C-reactive protein. In the whole group, IL-6 values were more closely related to the parameters evaluating insulin resistance than leptin or TNF alpha values. VLCD resulted in weight loss and decreased body fat mass (similar to 3 kg). Insulin sensitivity was improved with no significant change in bath serum and adipose tissue TNF alpha levels. In contrast, VLCD induced significant decreases in IL-6 and leptin levels in both adipose tissue and serum. These results suggest that, as for leptin, circulating IL-6 concentrations reflect, at least in part, adipose tissue production. The reduced production and serum concentrations after weight loss could play a role in the improved sensitivity to insulin observed in these patients.