POSITRON EMISSION TOMOGRAPHIC SCAN INVESTIGATIONS OF HUNTINGTONS-DISEASE - CEREBRAL METABOLIC CORRELATES OF COGNITIVE FUNCTION
POSITRON EMISSION TOMOGRAPHIC SCAN INVESTIGATIONS OF HUNTINGTONS-DISEASE - CEREBRAL METABOLIC CORRELATES OF COGNITIVE FUNCTION
复制标题
DOI：
10.1002/ana.410230603
复制
发表时间：
1988-06-01
影响因子：
11.2
通讯作者：
YOUNG, AB
中科院分区：
文献类型：
--
作者：
BERENT, S;GIORDANI, B;YOUNG, AB
采用正电子发射断层扫描（PET）对15例早期至中期无药物亨廷顿病（HD）患者的18f -2-氟-2-脱氧-d -葡萄糖摄取和神经功能、学习、记忆和一般智力的定量测量进行评估。与一组正常志愿者相比，HD患者在PET扫描上显示尾状核（p < 0.001）和壳核（p < 0.001）的代谢较低。患者组言语学习记忆神经心理指标与尾状核代谢呈显著正相关，正常组无显著正相关。视觉空间学习没有反映出类似的模式，但HD组的表现智商与尾状核和壳核代谢均呈正相关。词汇量水平与大脑结构无关。讨论的重点是这些和其他观察到的大脑-行为关系，以及这些发现对一般行为（如涉及应对和适应的行为）的影响。
Fifteen drug-free patients with early to mid-stage Huntington''s disease (HD) were evaluated with positron emission tomographic (PET) scans of 18F-2-fluoro-2-deoxy-D-glucose uptake and quantitative measures of neurological function, learning, memory, and general intelligence. In comparison with a group of normal volunteers, the HD patients showed lower metabolism in both caudate (p < 0.001) and putamen (p < 0.001) on PET scans. A significant and positive relationship was found between neuropsychological measures of verbal learning and memory and caudate metabolism in the patient group but not in the normal group. Visual-spatial learning did not reflect a similar pattern, but performance intelligence quotient was positively related to both caudate and putamen metabolism in the HD group. Vocabulary level was unrelated to either brain structure. Discussion focuses on these and other observed brain-behavior relationships and on the implications of these findings for general behaviors such as those involved in coping and adaptation.