Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp AS-79
Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp AS-79
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DOI：
10.3390/md15050137
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发表时间：
2017-05-01
期刊：
影响因子：
5.4
通讯作者：
Wang, Bin-Gui
中科院分区：
文献类型：
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作者：
Hu, Xue-Yi;Meng, Ling-Hong;Wang, Bin-Gui
从海葵衍生真菌Penicillium sp. AS-79中分离得到三个新的吲哚二萜类化合物，即22-羟基剪羊毛碱F（1）、6-羟基雀稗碱（2）和7-O-乙酰基吲哚乙素SB（3），沿着8个相关的已知类似物（4-11）。这些化合物的结构和相对构型通过光谱数据的详细解释确定，并且它们的绝对构型通过ECD计算（1和2）和单晶X射线衍射（3）确定。其中一些化合物对水生和人类病原微生物具有显著的活性。
Three new indolediterpenoids, namely, 22-hydroxylshearinine F (1), 6-hydroxylpaspalinine (2), and 7-O-acetylemindole SB (3), along with eight related known analogs (4-11), were isolated from the sea-anemone-derived fungus Penicillium sp. AS-79. The structures and relative configurations of these compounds were determined by a detailed interpretation of the spectroscopic data, and their absolute configurations were determined by ECD calculations (1 and 2) and single-crystal X-ray diffraction (3). Some of these compounds exhibited prominent activity against aquatic and human pathogenic microbes.