Replication control: Choreographing replication origins

Replication control: Choreographing replication origins
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DOI:
10.1016/s0960-9822(07)00483-6
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发表时间:
1998-10-22
期刊:
影响因子:
9.2
通讯作者:
Diffley, JFX
Diffley, JFX
中科院分区:
生物学1区
文献类型:
--
作者:
Diffley, JFX

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芽殖酵母复制起点在S期根据预定的时间程序被激活。最近的两项研究表明,这个程序至少在一定程度上是由s期促进细胞周期蛋白执行的,这些细胞周期蛋白的作用是组装包括Cdc45蛋白在内的起始前复合物。
Budding yeast replication origins are activated during S phase according to a predetermined temporal programme. Two recent studies indicate that this programme is executed, at least in part, by the S-phase-promoting cyclins that act to assemble a pre-initiation complex which includes the Cdc45 protein.