Coordinated events of nuclear assembly
Coordinated events of nuclear assembly
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DOI：
10.1016/j.ceb.2016.12.008
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发表时间：
2017-06-01
影响因子：
7.5
通讯作者：
Ullman, Katharine S.
中科院分区：
文献类型：
--
作者：
LaJoie, Dollie;Ullman, Katharine S.
每次后生动物细胞进行开放有丝分裂时，细胞核被拆除，以便将DNA内容物分配给子细胞。染色体分离后，染色质表面的变化导致核结构的重建。蛋白质预定核膜吸引染色质和伴随招募膜。当核膜和蛋白质成分扩散到染色质外被时，不同的区域出现了一些富含快速孔形成的区域，另一些区域被微管占据，微管仍然附着在动粒上。微管连接提供了物理屏障，必须重塑以使核被膜密封。最初以核膜蛋白质的对比库为特征的新生核膜区域随着核扩张并进入间期而迅速聚结。
Each time a metazoan cell undergoes open mitosis, the nucleus is dismantled in order to partition DNA content to the daughter cells. After chromosomes separate, changes at the chromatin surface usher in reestablishment of nuclear architecture. Proteins destined for the nuclear envelope are attracted to chromatin and concomitantly recruit membrane. As nuclear envelope and protein constituents spread to coat chromatin, distinct regions emerge-some rich in rapid pore formation, others occupied by microtubules that remain attached to kinetochores. Microtubule connections present physical barriers that must be remodeled in order for the nuclear envelope to seal. Regions of the nascent nuclear envelope that are initially characterized by contrasting repertoires of nuclear envelope proteins rapidly coalesce as nuclei expand and enter interphase.