Reduced frontal functional asymmetry in schizophrenia during a cued continuous performance test assessed with near-infrared spectroscopy
Reduced frontal functional asymmetry in schizophrenia during a cued continuous performance test assessed with near-infrared spectroscopy
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DOI：
10.1093/oxfordjournals.schbul.a033505
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发表时间：
2000-01-01
影响因子：
6.6
通讯作者：
Strik, WK
中科院分区：
文献类型：
--
作者：
Fallgatter, AJ;Strik, WK
近红外光谱（NIRS）技术利用氧合血红蛋白（O（2）Hb）和脱氧血红蛋白（HHb）独特的光学特性，可在活体内无创测量脑组织中氧合血红蛋白（O（2）Hb）和脱氧血红蛋白（HHb）浓度的变化。之前对健康受试者的近红外光谱研究（Fallgatter和Strik 1997）发现，在连续性能测试（CPT）期间，右额叶激活的迹象与正电子发射断层扫描（PET）和事件相关电位研究的结果一致。适应症包括右额叶血氧变化，符合血流动力学反应，沿着左额叶HHb显著增加。本研究调查了在CPT执行过程中，一组9名精神分裂症患者是否存在这种特征性偏侧额叶NIRS激活模式。与先前的研究相反，在精神分裂症受试者中没有发现整体或半球激活效应。两项研究结果的直接比较证实了组间差异，精神分裂症患者缺乏侧化激活。此外，精神分裂症患者在休息时和激活时左/右HHb比值有升高的趋势。这一发现被解释为特定侧额叶反应性降低的迹象，可能是基于左半球功能缺陷。
Near-infrared spectroscopy (NIRS) allows noninvasive, in vivo measurement of changes in the concentrations of oxygenated hemoglobin (O(2)Hb) and deoxygenated hemoglobin (HHb) in brain tissue based on their distinctive optical properties. A previous NIRS investigation on healthy subjects (Fallgatter and Strik 1997) found indications of right frontal activation during a Continuous Performance Test (CPT) that are consistent with results from positron emission tomography (PET) and event-related potentials studies. The indications consisted of right frontal blood oxygenation changes, consistent with a hemodynamic response, along with a significant left frontal increase in HHb The current study investigated whether this characteristic lateralized frontal NIRS activation pattern was present in a group of nine schizophrenia patients during the execution of a CPT. In contrast to the previous study, no overall or hemispheric activation effects were found in the schizophrenia subjects. Direct comparison of the results of the two studies confirmed group differences, with a lack of lateralized activation in schizophrenia patients. Furthermore, a trend of higher left/right HHb ratios at rest and during activation was found in patients with schizophrenia. The finding is interpreted as a sign of reduced specific lateralized frontal reactivity, possibly based on a left hemisphere functional deficit.