Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats.
Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats.
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发表时间：
2007
期刊：
影响因子：
3.5
通讯作者：
K. Takata;Y. Kitamura;Daijiro Yanagisawa;S. Morikawa;Masahito Morita;T. Inubushi;D. Tsuchiya;Saori Chishiro;Mana Saeki;T. Taniguchi;S. Shimohama;I. Tooyama
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作者：
K. Takata;Y. Kitamura;Daijiro Yanagisawa;S. Morikawa;Masahito Morita;T. Inubushi;D. Tsuchiya;Saori Chishiro;Mana Saeki;T. Taniguchi;S. Shimohama;I. Tooyama
用淀粉样蛋白-β（Abeta）肽免疫，阿尔茨海默病（AD）的治疗方法，降低脑Abeta，并且小胶质细胞Abeta吞噬作用已被提出作为Abeta降低机制。我们在海马内注射Abeta后立即将大鼠小胶质细胞移植到大鼠侧脑室，然后研究外源性小胶质细胞对Abeta清除的贡献。通过磁共振成像和组织化学分析检测外源性小胶质细胞从侧脑室迁移到Abeta斑块，并且通过移植增加Abeta的清除。这些结果表明，外源性小胶质细胞的治疗方法在AD的可能有用。
Immunization with amyloid-beta (Abeta) peptides, a therapeutic approach in Alzheimer's disease (AD), reduces brain Abeta, and microglial Abeta phagocytosis has been proposed as an Abeta-lowering mechanism. We transplanted rat microglia into the rat lateral ventricle just after intra-hippocampal Abeta injection, and then investigated the contribution of exogenous microglia to Abeta clearance. Migration of exogenous microglia from the lateral ventricle to Abeta plaque was detected by magnetic resonance imaging and histochemical analysis, and the clearance of Abeta was increased by transplantation. These results suggest the possible usefulness of exogenous microglia to the therapeutic approach in AD.