Designing Neural Networks in Culture: Experiments are described for controlled growth, of nerve cells taken from rats, in predesigned geometrical patterns on laboratory culture dishes.
Designing Neural Networks in Culture: Experiments are described for controlled growth, of nerve cells taken from rats, in predesigned geometrical patterns on laboratory culture dishes.
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DOI：
10.1109/jproc.2009.2039029
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发表时间：
2010-03-01
期刊：
影响因子：
--
通讯作者：
Brewer GJ
中科院分区：
文献类型：
--
作者：
Wheeler BC;Brewer GJ
技术已经进步到可以在培养皿中设计和生长神经元的活网络（具有预定义的几何形状和令人惊讶的良好保真度）。在这里，我们概述了设计要素，强调改变细胞培养表面的光刻技术，从而影响神经网络的附着和生长。该领域的先进功能使得设计所需复杂性的网络成为可能。解决的其他问题包括神经胶质细胞和介质对活动的影响以及将设计扩展到三个维度的潜力。研究人员正在通过刺激神经网络的功能来推进分析和控制的艺术和科学，包括利用其几何形式来影响功能特性的能力。
Technology has advanced to where it is possible to design and grow—with predefined geometry and surprisingly good fidelity—living networks of neurons in culture dishes. Here we overview the elements of design, emphasizing the lithographic techniques that alter the cell culture surface which in turn influences the attachment and growth of the neural networks. Advanced capability in this area makes it possible to design networks of desired complexity. Other issues addressed include the influence of glial cells and media on activity and the potential for extending the designs into three dimensions. Investigators are advancing the art and science of analyzing and controlling through stimulation the function of the neural networks, including the ability to take advantage of their geometric form in order to influence functional properties.