A new method for accurate in vivo mapping of human brain connections using microstructural and anatomical information
A new method for accurate in vivo mapping of human brain connections using microstructural and anatomical information
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一种利用显微结构和解剖学信息精确绘制人脑连接的新方法
DOI：
10.1126/sciadv.aba8245
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发表时间：
2020-07-01
期刊：
影响因子：
13.6
通讯作者：
Daducci, Alessandro
中科院分区：
文献类型：
--
作者：
Schiavi, Simona;Ocampo-Pineda, Mario;Daducci, Alessandro
弥散磁共振成像是一种非侵入性成像方式，已被广泛用于文献中，以研究在广泛的神经系统条件下使用纤维束成像的大脑的神经元结构。然而，最近的研究强调，重建的解剖准确性本质上是有限的，并挑战其适当性。已经提出了几种解决方案来解决这个问题，但没有一个被证明是有效的，以克服这一根本性的限制。在这项工作中，我们提出了一种新的处理框架，注入到重建问题的基本先验知识的大脑解剖和组织，并评估其有效性，使用模拟和真实的人脑数据。我们的研究结果表明，我们提出的方法大大提高了估计的大脑网络的准确性，因此，代表了连通性研究的重要一步。
Diffusion magnetic resonance imaging is a noninvasive imaging modality that has been extensively used in the literature to study the neuronal architecture of the brain in a wide range of neurological conditions using tractography. However, recent studies highlighted that the anatomical accuracy of the reconstructions is inherently limited and challenged its appropriateness. Several solutions have been proposed to tackle this issue, but none of them proved effective to overcome this fundamental limitation. In this work, we present a novel processing framework to inject into the reconstruction problem basic prior knowledge about brain anatomy and its organization and evaluate its effectiveness using both simulated and real human brain data. Our results indicate that our proposed method dramatically increases the accuracy of the estimated brain networks and, thus, represents a major step forward for the study of connectivity.