8-OH-DPAT stimulates gastric acid secretion through a vagal-independent, adrenal-mediated mechanism.
8-OH-DPAT stimulates gastric acid secretion through a vagal-independent, adrenal-mediated mechanism.
复制标题
8-OH-DPAT 通过不依赖迷走神经、肾上腺介导的机制刺激胃酸分泌。
DOI：
10.1016/0014-2999(95)00331-e
复制
发表时间：
1995
影响因子：
5
通讯作者：
StephensJr,RL
中科院分区：
文献类型：
--
作者：
Gidener,S;LePard,KJ;StephensJr,RL
5-羟色胺(5-羟色胺，5-HT)是胃肠道的一种神经内分泌成分。5-HT1A受体既存在于脑中，也被放射自显影证实在大鼠胃中密度很高。然而，5-HT1A受体在调节胃功能中的生理作用尚不清楚。本文比较了选择性5-羟色胺受体激动剂(±)-8-羟基-2-(N-二丙氨基)四氢萘(8-OH-DPAT)和5-羟色胺(5-HT)对急性乌拉坦麻醉胃瘘大鼠胃酸分泌功能的影响。5-羟色胺抑制胃酸分泌，而8-OH-DPAT则呈剂量依赖性地刺激胃酸分泌。双侧颈迷走神经切断或腹腔神经节切除不能逆转8-OH-DPAT对胃酸分泌的影响。然而，8-OH-DPAT对胃酸的增强作用可通过急性肾上腺切除或动脉内紧密给药而减弱，但不能减弱咪唑克生的作用。因此，这些数据表明选择性5-HT1A受体激动剂8-OH-DPAT可能通过肾上腺依赖的机制增强胃的分泌功能。
Serotonin (5-hydroxytryptamine, 5-HT) is a neuroendocrine component of the gastrointestinal tract. 5-HT1Areceptors exist both in the brain and have been demonstrated autoradiographically in high density in the rat stomach. However, the physiologic role of 5-HT1Areceptors in modulating gastric function is not known. The effect of the selective 5-HT1Areceptor agonist, (±)-8-hydroxy-2-(n-dipropylamino)tetralin (8-OH-DPAT), on gastric acid secretory function was compared to 5-HT in acute, urethane-anesthetized gastric-fistulated rats during pentagastrin infusion. 5-HT inhibited, but 8-OH-DPAT stimulated, gastric acid secretion in a dose-dependent manner. Bilateral cervical vagotomy or celiac ganglionectomy did not reverse the effect of 8-OH-DPAT on acid secretion. However, the enhancement of acid by 8-OH-DPAT was attenuated by acute adrenalectomy or close intra-arterial administration of spiperone, but not idazoxan. Thus, the data suggest that the selective 5-HT1Areceptor agonist 8-OH-DPAT may augment gastric secretory function via an adrenal-dependent mechanism.