Metabolic defects in splenic B cell compartments from patients with liver cirrhosis.
Metabolic defects in splenic B cell compartments from patients with liver cirrhosis.
复制标题
肝硬化患者脾 B 细胞区室的代谢缺陷。
DOI：
10.1038/s41419-020-03060-1
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发表时间：
2020-10-24
影响因子：
9
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Huang M;Liu X;Ye H;Zhao X;Zhao J;Liu Y;He X;Qu M;Pan J;Hou B;Cheng Y;Liu Z;Li Z;Liu L;Sun J;Zhang S;Zhang Z
肝硬化与疫苗反应缺陷和感染增加有关。肝硬化患者的 B 细胞区室失调已被注意到，但尚未得到很好的表征，特别是在脾脏中。在这里，我们全面研究了肝硬化患者脾脏和外周血中 B 细胞的扰动。我们发现肝硬化显着耗尽了转换和非转换的脾记忆 B 细胞，这在组织学上得到了进一步证实。 Bulk RNA-seq 揭示了显着的代谢缺陷是脾 B 细胞功能受损的潜在机制。在功能上，与健康对照者相比，肝硬化患者的脾记忆 B 细胞表现出强烈的代谢缺陷和增殖减少。因此，肝硬化广泛扰乱脾脏和外周 B 细胞区室，这可能导致肝硬化期间体液免疫缺陷。
Liver cirrhosis is associated with defective vaccine responses and increased infections. Dysregulated B cell compartments in cirrhotic patients have been noticed but not well characterized, especially in the spleen. Here, we comprehensively investigated B cell perturbations from the spleens and peripheral blood of cirrhotic patients. We found that liver cirrhosis significantly depleted both switched and nonswitched splenic memory B cells, which was further confirmed histologically. Bulk RNA-seq revealed significant metabolic defects as the potential mechanism for the impaired splenic B cell functions. Functionally, the splenic memory B cells from cirrhotic patients showed strong metabolic defects and reduced proliferation compared with those from healthy controls. Thus, liver cirrhosis extensively disturbs the splenic and peripheral B cell compartments, which may contribute to defective humoral immunity during liver cirrhosis.
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影响因子：
4.6
作者：
Chang LY;Li Y;Kaplan DE
通讯作者：
Kaplan DE
影响因子：
3.7
作者：
Clavarino G;Delouche N;Vettier C;Laurin D;Pernollet M;Raskovalova T;Cesbron JY;Dumestre-Pérard C;Jacob MC
通讯作者：
Jacob MC
影响因子：
3.8
作者：
Carrillo, Jorge;Negredo, Eugenia;Blanco, Julia
通讯作者：
Blanco, Julia
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20.3
作者：
Daridon, Capucine;Loddenkemper, Christoph;Doerner, Thomas
通讯作者：
Doerner, Thomas
影响因子：
4
作者：
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通讯作者：
Ginsberg, Mark H.