Toxicology studies with N-acetylglycine
Toxicology studies with N-acetylglycine
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DOI：
10.1016/j.fct.2010.02.031
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发表时间：
2010-05-01
影响因子：
4.3
通讯作者：
Delaney, Bryan
中科院分区：
文献类型：
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作者：
Harper, Marc S.;Shen, Z. Amanda;Delaney, Bryan
N-乙酰甘氨酸（NAGly）已被确定为许多食物的次要成分。本文报告了NAGly的体外和体内遗传毒性、急性口服和重复剂量饮食毒理学研究结果。NAGly体外细菌试验菌株或在小鼠中进行的体内骨髓微核研究均未观察到遗传毒性证据。在Sprague道利大鼠中，在以2000 mg/kg体重的剂量急性经口管饲NAGly后或在以100、500或1000 mg/kg体重/天的目标剂量重复饮食暴露于NAGly 28天后，未观察到死亡或不良作用的证据。在任何给药组中，均未观察到体重、摄食量或临床病理学反应变量的生物学显著性差异或供试品相关差异。基于这些结果，可以得出结论，NAGly无遗传毒性或急性毒性。此外，NAGly重复剂量饮食暴露的全身毒性的无明显不良作用水平（NOAEL）对于雄性大鼠为898.9 mg/kg体重/天，对于雌性大鼠为989.9 mg/kg体重/天。(C)2010爱思唯尔有限公司版权所有。
N-acetylglycine (NAGly) has been identified as a minor constituent of numerous foods. The current paper reports the outcome of in vitro and in vivo genotoxicity, acute oral and repeated dose dietary toxicology studies conducted with NAGly. No evidence of genotoxicity was observed with NAGly in vitro bacterial tester strains or in vivo bone marrow micronucleus studies conducted in mice. No mortalities or evidence of adverse effects were observed in Sprague Dawley rats following acute oral gavage with NAGly at a dose of 2000 mg/kg of body weight or following repeated dose dietary exposure to NAGly at targeted doses of 100, 500, or 1000 mg/kg of body weight/day for 28 days. No biologically significant or test substance related differences were observed in body weights, feed consumption, or clinical pathology response variables in any of the treatment groups. Based on these results it was concluded that NAGly is not genotoxic or acutely toxic. Further, the no-observed adverse-effect-level (NOAEL) for systemic toxicity from repeated dose dietary exposure to NAGly was 898.9 mg/kg of body weight/day for male rats and 989.9 mg/kg of body weight/day for female rats. (C) 2010 Elsevier Ltd. All rights reserved.