Reduced Hippocampal Activity in Youth with Posttraumatic Stress Symptoms: An fMRI Study
Reduced Hippocampal Activity in Youth with Posttraumatic Stress Symptoms: An fMRI Study
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DOI：
10.1093/jpepsy/jsp112
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发表时间：
2010-06-01
影响因子：
3.6
通讯作者：
Reiss, Allan L.
中科院分区：
文献类型：
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作者：
Carrion, Victor G.;Haas, Brian W.;Reiss, Allan L.
目的 经历过人际创伤并患有创伤后应激症状 (PTSS) 的青少年会出现影响其发展的认知缺陷。我们的目标是调查患有 PTSS 的青少年在执行记忆处理任务时海马体的功能。方法 27 名 10-17 岁青少年（16 名患有 PTSS 和 11 名健康对照）在接受功能磁共振成像扫描时编码并检索视觉呈现的名词（言语陈述性记忆任务）。结果 PTSS 组在任务的检索部分中表现出右侧海马体的激活减少。此外，回避和麻木症状的严重程度与检索过程中左海马激活的减少相关。结论 在有人际创伤史的青少年中，言语记忆任务期间海马活动的减少可能是 PTSS 的神经功能标志。这项研究的结果可能有助于针对性治疗的开发，并且在评估 PTSS 的治疗结果时可能有用。
Objective Youth who experience interpersonal trauma and have posttraumatic stress symptoms (PTSS) develop cognitive deficits that impact their development. Our goal is to investigate the function of the hippocampus in adolescents with PTSS during a memory processing task. Methods Twenty-seven adolescents between the ages of 10-17 years (16 with PTSS and 11 healthy controls) encoded and retrieved visually presented nouns (Verbal Declarative Memory Task) while undergoing fMRI scanning. Results The PTSS group demonstrated reduced activation of the right hippocampus during the retrieval component of the task. Further, severity of symptoms of avoidance and numbing correlated with reduced left hippocampal activation during retrieval. Conclusions Decreased activity of the hippocampus during a verbal memory task may be a neurofunctional marker of PTSS in youth with history of interpersonal trauma. The results of this study may facilitate the development of focused treatments and may be of utility when assessing treatment outcome for PTSS.