Understanding the neurobiology of CD200 and the CD200 receptor: a therapeutic target for controlling inflammation in human brains?
Understanding the neurobiology of CD200 and the CD200 receptor: a therapeutic target for controlling inflammation in human brains?
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DOI：
10.2217/fnl.13.14
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发表时间：
2013-05
期刊：
影响因子：
1.3
通讯作者：
Lue LF
中科院分区：
文献类型：
--
作者：
Walker DG;Lue LF
CD 200及其受体CD 200受体（CD 200 R）在控制损伤性炎症过程中具有独特的作用。目前，CD 200的唯一功能是作为CD 200 R的配体。这些蛋白质相互作用，导致表达CD 200 R的细胞激活抗炎信号。当这种相互作用随着衰老或疾病而变得不足时，就会发生慢性炎症，实验动物研究已经证明了破坏大脑中CD 200-CD 200 R相互作用的后果，但在人类大脑中的研究很少。神经元CD 200的缺乏可以解释人类神经退行性疾病（如阿尔茨海默病、帕金森病和多发性硬化症）中的慢性炎症;然而，CD 200 R的小胶质细胞表达的缺乏也可能具有功能意义。本综述的目的是评估有关CD 200-CD 200 R相互作用在大脑中的作用的数据，以确定这是否可以成为具有炎症成分的人脑疾病的治疗靶点，以及需要进行哪些额外的研究。
CD200 and its receptor, CD200 receptor (CD200R), have uniaue roles in controlling damaging inflammatory processes. At present, the only identified function for CD200 is as a ligand for CD200R. These proteins interact resulting in the activation of anti-inflammatory signaling by CD200R-expressing cells. When this interaction becomes deficient with aging or disease, chronic inflammation occurs, Experimental animal studies have demonstrated the consequences of disrupting CD200–CD200R interactions in the brain, but there have been few studies in human brains. Deficiency in neuronal CD200 may explain the chronic inflammation in human neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease and multiple sclerosis; however, deficits in the microglial expression of CD200R may also be of functional significance. The purpose of this review is to assess the data regarding the role of CD200–CD200R interactions in relation to the brain in order to determine if this could be a therapeutic target for human brain diseases with inflammatory components, and what additional studies are needed.