Neonatal outcome after preimplantation genetic diagnosis
Neonatal outcome after preimplantation genetic diagnosis
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DOI：
10.1016/j.fertnstert.2014.06.023
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发表时间：
2014-10-01
影响因子：
6.7
通讯作者：
Schimmel, Michael S.
中科院分区：
文献类型：
--
作者：
Eldar-Geva, Talia;Srebnik, Naama;Schimmel, Michael S.
目的：探讨植入前遗传学诊断（PGD）胚胎活检是否对新生儿结局产生影响。设计：前瞻性随访队列。地点：三级大学附属医学中心。患者：PGD后出生的242名儿童，胞浆内单精子注射（ICSI）后出生的242名儿童（每组158对单胎和42对双胞胎），以及自然受孕（SC）后出生的733名儿童（493 例单胎，120 例双胞胎），匹配母亲年龄、产次和体重指数。干预措施：无。主要结果指标：胎龄、出生体重、早产（
Objective: To examine whether embryo biopsy for preimplantation genetic diagnosis (PGD) influences neonatal outcomes.Design: Prospective follow-up cohort.Setting: Tertiary university-affiliated medical center.Patient(s): 242 children born after PGD, 242 children born after intracytoplasmic sperm injection (ICSI) (158 singletons and 42 twins pairs in each group), and 733 children born after a spontaneous conception (SC) (493 singletons, 120 twins pairs), matched for maternal age, parity, and body mass index.Intervention(s): None.Main Outcome Measure(s): Gestational age, birth weight, prematurity (