Chemokine signaling in cancer: one hump or two?
Chemokine signaling in cancer: one hump or two?
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DOI：
10.1016/j.semcancer.2008.10.001
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发表时间：
2009-04
影响因子：
14.5
通讯作者：
Rubin JB
中科院分区：
文献类型：
--
作者：
Rubin JB
Chemokines and their receptors play essential roles in the development and function of multiple tissues. Chemokine expression, particularly CXCL12 and its receptor CXCR4, has prognostic significance in several cancers apparently due to chemokine mediated growth and metastatic spread. These observations provide the rationale for pursuing CXCR4 inhibition for cancer chemotherapy. However, the multiple homeostatic functions of CXCR4 may preclude global inhibition as a therapeutic strategy. Here I review CXCR4 signaling and how it might differ in normal and transformed cells with special emphasis on the role that altered CXCR4 counter-regulation might play in tumor biology. I propose that CXCR4 mediates unique signals in cancer cells as a consequence of abnormal counter-regulation and that this results in novel biological responses. The importance of testing this hypothesis lies in the possibility that targeting abnormal CXCR4 signaling might provide an anti-tumor effect without disturbing normal CXCR4 functions.
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影响因子：
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通讯作者：
Henson, GW
高度恶性的人神经胶质瘤优先表达趋化因子受体CXCR4及其与患者生存率低的关系
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Wang, Ji Ming
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Burton, GF
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Snyderman, R
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Druey, KM;Blumer, KJ;Kehrl, JH
通讯作者：
Kehrl, JH