Alterations of skeletal muscle metabolism in humans studied by phosphorus 31 magnetic resonance spectroscopy in congestive heart failure.
Alterations of skeletal muscle metabolism in humans studied by phosphorus 31 magnetic resonance spectroscopy in congestive heart failure.
复制标题
通过磷 31 磁共振波谱研究充血性心力衰竭中人体骨骼肌代谢的变化。
DOI：
10.1016/s0002-9149(88)80012-2
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Radda,GK
中科院分区：
文献类型：
--
作者：
Rajagopalan,B;Conway,MA;Massie,B;Radda,GK
在充血性心力衰竭患者和与年龄相关的对照组中检查了优势臂手指屈肌的肌肉代谢。运动过程中磷酸肌酸的利用和pH值的降低在患者中显著高于对照组。其中一些患者的恢复速度较慢。与对照组相比，患者在休息或运动时前臂血流的测量值没有显著降低。在一些患者的运动过程中，无机磷酸盐峰分裂，表明他们的肌肉中存在更多的糖酵解纤维。这些观察结果表明，心力衰竭患者的骨骼肌可能存在代谢异常，而不是由于营养性血流减少。这可能部分解释了这些患者的心功能测量值与运动耐量之间缺乏相关性。
Muscle metabolism of the finger flexor muscle of the dominant arm was examined in patients with congestive heart failure and age-related controls. Phosphocreatine utilization and decrease in pH during exercise was significantly greater in patients than in controls. Recovery rates were slow in some of these patients. Measurements of forearm blood flow at rest or during exercise were not significantly reduced in patients compared with controls. The inorganic phosphate peak was split during exercise in some of the patients, suggesting the presence of more glycolytic fibers in their muscles. These observations suggest that metabolic abnormalities may be present in the skeletal muscles of patients with heart failure that are not due to reduced nutritive blood flow. This may, in part, explain the lack of correlation between measurements of cardiac function and exercise tolerance in these patients.