Reinstating olfactory bulb derived limbic gamma oscillations alleviates depression
Reinstating olfactory bulb derived limbic gamma oscillations alleviates depression
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DOI：
10.1101/2022.02.01.478683
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发表时间：
2022-02
期刊：
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通讯作者：
Qun Li;Yuichi Takeuchi;Jiale Wang;Lívia Barcsai;L. K. Pedraza;Gábor Kozák;Shinya Nakai;S. Kato;Kazuto Kobayashi;Masahiro Ohsawa;Magor L. Lőrincz;Orrin Devinsky;György Buzsáki;A. Berényi
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作者：
Qun Li;Yuichi Takeuchi;Jiale Wang;Lívia Barcsai;L. K. Pedraza;Gábor Kozák;Shinya Nakai;S. Kato;Kazuto Kobayashi;Masahiro Ohsawa;Magor L. Lőrincz;Orrin Devinsky;György Buzsáki;A. Berényi
虽然重性抑郁症的病因尚不清楚，但伽马振荡损伤最近成为重性抑郁症的潜在生物标志物。嗅球（OB）是全脑伽马振荡的主要来源，嗅球切除术是抑郁症的动物模型。本研究表明，化学发生抑制OB神经元活动或暂时抑制OB到梨状皮质突触传递会降低与抑郁样行为相关的多个脑区的伽马振荡功率。为了评估伽马振荡抑制和弥漫性抑制之间的假设联系，我们采用了皮层区域的伽马相位依赖闭环神经调节，以原生OB输出为节奏。这一过程减轻了动物的抑郁样行为，并表明恢复伽马振荡可能改善人类的抑郁。边缘伽马振荡在抑郁症中的作用
Although the etiology of major depressive disorder remains poorly understood, impairment of gamma oscillations recently emerged as a potential biomarker for major depression. The olfactory bulb (OB) is a major source of brain wide gamma oscillations and bulbectomy is an animal model for depression. Here we demonstrate that chemogenetic suppression of OB neuronal activity or temporally suppressing the OB to pyriform cortex synaptic transmission decreased gamma oscillation power in multiple brain areas associated with depression-like behaviors. To assess the hypothesized link between depression and diffuse depression of gamma oscillations, we employed gamma phase-dependent closed loop neuromodulation of cortical areas, paced by the native OB output. This procedure alleviated depressive-like behaviors in animals and suggests that restoring gamma oscillations may improve depression in humans. One Sentence Summary Role of limbic gamma oscillations in depression