Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1).
Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1).
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注射帕拉米韦可减轻感染高毒力流感病毒 A/Vietnam/1203/04 (H5N1) 的雪貂和小鼠的疾病并促进其存活。
DOI：
10.1016/j.virol.2007.12.029
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发表时间：
2008
期刊：
影响因子：
3.7
通讯作者：
Paessler,Slobodan
中科院分区：
文献类型：
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作者：
Yun,NadezhdaE;Linde,NathanielS;Zacks,MicheleA;Barr,IanG;Hurt,AeronC;Smith,JeanonN;Dziuba,Natallia;Holbrook,MichaelR;Zhang,Lifang;Kilpatrick,JohnM;Arnold,CShane;Paessler,Slobodan
在小鼠和雪貂中评价了注射用帕拉米韦对高致病性A型禽流感H5 N1的暴露后治疗效果。70%至80%的H5 N1感染的帕拉米韦治疗的小鼠和70%的奥司他韦治疗的小鼠在15天的研究期内存活，而对照组（载体）的存活率为36%。雪貂鼻内感染H5 N1，然后用多剂量帕拉米韦治疗。在三项试验中的两项中，帕拉米韦治疗导致16-18天期间的存活率统计学显著增加，与模拟治疗或未治疗的动物相比，存活率提高了40-64%。注射帕拉米韦可减轻病毒引起的疾病，降低肺和脑中的感染性病毒滴度，并促进鼻内感染这种高度神经毒性分离株的雪貂的存活。单次肌肉注射帕拉米韦可保护小鼠免受高致病性禽流感感染后的严重疾病后果，多剂量治疗对雪貂有效。
The post-exposure therapeutic efficacy of injectable peramivir against highly pathogenic avian influenza type A H5N1 was evaluated in mice and in ferrets. Seventy to eighty percent of the H5N1-infected peramivir-treated mice, and 70% in the oseltamivir treated mice survived the 15-day study period, as compared to 36% in control (vehicle) group. Ferrets were infected intranasally with H5N1 followed by treatment with multiple doses of peramivir. In two of three trials, a statistically significant increase in survival over a 16–18 day period resulted from peramivir treatment, with improved survival of 40–64% in comparison to mock-treated or untreated animals. Injected peramivir mitigates virus-induced disease, reduces infectious virus titers in the lungs and brains and promotes survival in ferrets infected intranasally with this highly neurovirulent isolate. A single intramuscular peramivir injection protected mice against severe disease outcomes following infection with highly pathogenic avian influenza and multi-dose treatment was efficacious in ferrets.