Insecticide resistance genes in mosquitoes: Their mutations, migration, and selection in field populations
Insecticide resistance genes in mosquitoes: Their mutations, migration, and selection in field populations
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DOI：
10.1093/oxfordjournals.jhered.a023035
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发表时间：
1996-11-01
影响因子：
3.1
通讯作者：
Raymond, M
中科院分区：
文献类型：
--
作者：
Pasteur, N;Raymond, M
在过去的50年里，杀虫剂被广泛用于控制昆虫种群，许多昆虫物种对几种杀虫剂产生了抗性，这些抗性主要是由于两种机制：杀虫剂靶蛋白突变（导致其对相关杀虫剂家族的亲和力降低），并增加解毒作用，最近的分子研究表明，赋予抗性的突变是罕见的，有时在任何给定的物种中都是独特的事件，其中一些基因的广泛地理分布只能用种群水平上的迁移和选择之间的平衡来解释。
Insecticides have been used intensively to control insect populations over the last 50 years and many species of insects have developed resistance to several families of insecticides, These resistances are mainly due to two mechanisms: mutation of the insecticide target protein (leading to a decrease in its affinity for the concerned insecticide family), and increased detoxification, Recent molecular studies suggest that the mutations conferring resistance are rare and sometimes unique events in any given species, The wide geographic distribution of some of these genes can then only be explained by the balance between migration and selection at the population level.