Multimodal Chemosensory Circuits Controlling Male Courtship in Drosophila.
Multimodal Chemosensory Circuits Controlling Male Courtship in Drosophila.
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DOI：
10.1016/j.neuron.2015.07.025
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发表时间：
2015-09-02
期刊：
影响因子：
16.2
通讯作者：
Ruta V
中科院分区：
文献类型：
--
作者：
Clowney EJ;Iguchi S;Bussell JJ;Scheer E;Ruta V
在整个动物王国中，内部状态会产生持久和自我延续的行为链。在果蝇中，雄性本能地追求雌性，通过激活性二态P1中间神经元引发漫长而复杂的求爱仪式。味觉信息素被认为是激活P1神经元，但决定它们进入求爱的感觉反应的电路机制仍然未知。在这里，我们使用电路映射和体内功能成像技术来跟踪味觉和嗅觉信息素电路到P1神经元的收敛点，并揭示它们的组合输入是如何选择性调谐到适当的性伴侣的。我们确定抑制，即使在响应求爱促进信息素，作为一个关键的电路元件，调谐和回火P1神经元活动。我们的研究结果表明，在果蝇中，平衡的兴奋和抑制是区分未来配偶的基础，并严格调节向求爱的过渡。
Throughout the animal kingdom, internal states generate long-lasting and self-perpetuating chains of behavior. In Drosophila, males instinctively pursue females with a lengthy and elaborate courtship ritual triggered by activation of sexually dimorphic P1 interneurons. Gustatory pheromones are thought to activate P1 neurons but the circuit mechanisms that dictate their sensory responses to gate entry into courtship remain unknown. Here, we use circuit mapping and in vivo functional imaging techniques to trace gustatory and olfactory pheromone circuits to their point of convergence onto P1 neurons and reveal how their combined input underlies selective tuning to appropriate sexual partners. We identify inhibition, even in response to courtship-promoting pheromones, as a key circuit element that tunes and tempers P1 neuron activity. Our results suggest a circuit mechanism in which balanced excitation and inhibition underlie discrimination of prospective mates and stringently regulate the transition to courtship in Drosophila.