Age Trends in Estradiol and Estrone Levels Measured Using Liquid Chromatography Tandem Mass Spectrometry in Community-Dwelling Men of the Framingham Heart Study
Age Trends in Estradiol and Estrone Levels Measured Using Liquid Chromatography Tandem Mass Spectrometry in Community-Dwelling Men of the Framingham Heart Study
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DOI：
10.1093/gerona/gls216
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发表时间：
2013-06-01
影响因子：
5.1
通讯作者：
Bhasin, Shalender
中科院分区：
文献类型：
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作者：
Jasuja, Guneet Kaur;Travison, Thomas G.;Bhasin, Shalender
男性雌二醇和雌酮水平的年龄趋势以及生活方式因素、共病情况、睾酮和性激素结合球蛋白如何影响这些年龄趋势仍然知之甚少，并在Fraurone Heart Study. Eestrone和雌二醇浓度的男性Fraurone后代中采用液相色谱串联质谱法测定早晨空腹样本。采用质量作用定律方程计算游离雌二醇，共有1,461名合格男性（平均年龄[SD] 61.19.5岁，体重指数[BMI] 28.84.5kg/m2）。总雌二醇和雌酮与年龄呈正相关，但游离雌二醇与年龄呈负相关。雌酮总量的增加大于雌二醇总量的增加。雌酮与吸烟、体重指数、睾酮呈正相关，总雌二醇和游离雌二醇与糖尿病、体重指数、睾酮和合并症呈正相关;此外，游离雌二醇与吸烟呈负相关。总的来说，年龄、BMI、睾酮和其他健康和行为因素仅解释了雌二醇水平18%的变异，解释了雌酮水平9%的变异。雌酮水平最高的五分位数的男性具有显著更高的年龄和BMI，并且吸烟、糖尿病和心血管疾病的患病率比其他人更高，而雌二醇水平最高的五分位数的男性具有比其他人更高的BMI。结果显示，年龄相关性显著增加，但BMI、糖尿病状态和其他合并症及健康行为的横截面差异仅部分解释了这一点。需要纵向研究来证实这些发现。
Age trends in estradiol and estrone levels in men and how lifestyle factors, comorbid conditions, testosterone, and sex hormonebinding globulin affect these age trends remain poorly understood, and were examined in men of the Framingham Heart Study.Estrone and estradiol concentrations were measured in morning fasting samples using liquid chromatography tandem mass spectrometry in men of Framingham Offspring Generation. Free estradiol was calculated using a law of mass action equation.There were 1,461 eligible men (mean age [SD] 61.19.5 years and body mass index [BMI] 28.84.5kg/m(2)). Total estradiol and estrone were positively associated with age, but free estradiol was negatively associated with age. Age-related increase in total estrone was greater than that in total estradiol. Estrone was positively associated with smoking, BMI, and testosterone, and total and free estradiol with diabetes, BMI, testosterone, and comorbid conditions; additionally, free estradiol was associated negatively with smoking. Collectively, age, BMI, testosterone, and other health and behavioral factors explained only 18% of variance in estradiol, and 9% of variance in estrone levels. Men in the highest quintile of estrone levels had significantly higher age and BMI, and a higher prevalence of smoking, diabetes, and cardiovascular disease than others, whereas those in the highest quintile of estradiol had higher BMI than others.Total estrone and estradiol levels in men, measured using liquid chromatography tandem mass spectrometry, revealed significant age-related increases that were only partially accounted for by cross-sectional differences in BMI, diabetes status, and other comorbidities and health behaviors. Longitudinal studies are needed to confirm these findings.