Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS
Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS
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DOI：
10.1385/ir:29:1-3:001
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发表时间：
2004-01-01
影响因子：
4.4
通讯作者：
Villinger, F
中科院分区：
文献类型：
--
作者：
Ansari, AA;Mayne, AE;Villinger, F
艾滋病毒等传染病的爆发，以及埃博拉病毒、汉坦病毒等疾病的爆发，都在电视上播出，引起了人们的关注。和最近SARS的爆发已经引起了对制剂的新的重大兴趣，更重要的是，引起了对疫苗学科学的新的重大兴趣，疫苗学科学以前在很大程度上是凭经验进行的。我们的实验室一直专注于使用重组非人灵长类动物细胞因子作为诱导猴抗原特异性免疫应答的连续疗法，因为大多数重组人细胞因子似乎具有免疫原性。本文提供了我们的工作与这些细胞因子，其中包括试图定义最佳的给药方案，导致最佳的初级和持久的记忆抗原特异性免疫反应的总结。
Outbreaks of infectious diseases such as HIV and the much televised and attention-getting outbreaks of diseases such as Ebola, Hantaviruses. and the most recent outbreak of SARS have induced a significant new interest in the formulations and more importantly the science of vaccinology, which has previously to a large extent been conducted empirically. Our laboratory has focused on the use of recombinant nonhuman primate cytokines as adjunctive therapies for inducing antigen-specific immune responses in monkeys because most recombinant human cytokines appear to be immunogenic. This article provides a summary of our work with such cytokines, which includes attempts to define optimum dosing schedules that lead to optimal primary and lasting memory antigen-specific immune responses.