Axonal transport of TREK and TRAAK potassium channels in rat sciatic nerves
Axonal transport of TREK and TRAAK potassium channels in rat sciatic nerves
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DOI：
10.1097/00001756-200004070-00006
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发表时间：
2000-04-07
期刊：
影响因子：
1.7
通讯作者：
Laduron, PM
中科院分区：
文献类型：
--
作者：
Bearzatto, B;Lesage, F;Laduron, PM
最近对TREK和TRAAK这两个新的钾离子通道的克隆、功能表达和脑定位，使我们研究了这两个通道是否存在于周围神经中，并通过轴突运输机制沿轴突移动。使用针对TREK和TRAAK肽的特异性抗体，我们发现大鼠坐骨神经中钾通道的免疫反应性在结扎上方和下方积累。这一过程是快速且双向的，表明这些通道与囊泡有关。这是关于钾离子通道轴突转运的首次报道。《神经病学杂志》（英文版）：927-930。
The recent cloning, functional expression and brain localization of two new potassium channels, TREK and TRAAK, led us to examine whether both channels are present in peripheral nerves and can move along axons by means of axonal transport mechanisms. Using specific antibodies directed against TREK and TRAAK peptides, we found that immunoreactivity for both potassium channels accumulates above and below a ligature in rat sciatic nerves. The process was rapid and bidirectional suggesting that the channels are associated with vesicles. This represents the first report on the axonal transport of potassium channels. NeuroReport 11:927-930 (C) 2000 Lippincott Williams & Wilkins.