Integrin β3 mediates cerebrovascular remodelling through Src/ClC‐3 volume‐regulated Cl− channel signalling pathway
Integrin β3 mediates cerebrovascular remodelling through Src/ClC‐3 volume‐regulated Cl− channel signalling pathway
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DOI：
10.1111/bph.12654
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发表时间：
2014-07
影响因子：
7.3
通讯作者：
Jia-Wei Zeng;Xiao-Guang Wang;M. Ma;Xiao-fei Lv;Jie Liu;Jia-Guo Zhou;Y. Guan
中科院分区：
文献类型：
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作者：
Jia-Wei Zeng;Xiao-Guang Wang;M. Ma;Xiao-fei Lv;Jie Liu;Jia-Guo Zhou;Y. Guan
脑血管重构是脑卒中的重要危险因素之一。潜在的机制尚不清楚。整合素β3和体积调节的ClC-3 Cl−通道最近被认为是血管细胞增殖的重要贡献者。因此，我们研究了整合素β3在脑血管重塑和相关Cl−信号通路中的作用。
Cerebrovascular remodelling is one of the important risk factors of stroke. The underlying mechanisms are unclear. Integrin β3 and volume‐regulated ClC‐3 Cl− channels have recently been implicated as important contributors to vascular cell proliferation. Therefore, we investigated the role of integrin β3 in cerebrovascular remodelling and related Cl− signalling pathway.