Dehydroepiandrosterone sulfate: kinetics of metabolism in normal young men and women.
Dehydroepiandrosterone sulfate: kinetics of metabolism in normal young men and women.
复制标题
硫酸脱氢表雄酮：正常年轻男性和女性的代谢动力学。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
Clark Af
中科院分区：
文献类型：
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作者：
Bird Ce;Masters;Clark Af
应用恒定输注技术研究了正常青年男女硫酸脱氢表雄酮（DHEAS）代谢动力学。正常年轻男性和女性的代谢清除率（MCR）（平均值+/- SEM）分别为15.2 +/- 1.7 1/24 h（8.2 +/- 0.7 1/m2/24 h）和11.8 +/- 0.8 1/24 h（7.3 +/- 0.4 1/m2/24 h）。再加上5.07 +/- 1.95和4.02 +/- 0.57 mumole/L的血浆水平，男性和女性的产血率分别为76.7 +/- 25.7和48.0 +/- 9.4 mumole/24 h。DHEAS转化为脱氢表雄酮（DHEA）的转化率男性为0.006，女性为0.004。由于DHEA相对于DHEAS的高代谢清除率和DHEAS的高产生率，每天产生的大部分DHEA可来自DHEAS。
The constant infusion technique was used to study the kinetics of dehydroepiandrosterone sulfate (DHEAS) metabolism in normal young men and women. The metabolic clearance rates (MCR) (means +/- SEM) for normal young men and women were 15.2 +/- 1.7 1/24 h (8.2 +/- 0.7 1/m2/24 h) and 11.8 +/- 0.8 1/24 h (7.3 +/- 0.4 1/m2/24 h) respectively. Coupled with the plasma levels of 5.07 +/- 1.95 and 4.02 +/- 0.57 mumole/L the resulting blood production rates were 76.7 +/- 25.7 and 48.0 +/- 9.4 mumole/24 h for men and women respectively. The conversion ratios for the conversion of DHEAS to dehydroepiandrosterone (DHEA) were 0.006 for men and 0.004 for women. Because of the high metabolic clearance rates for DHEA relative to those for DHEAS and the high production rates of DHEAS most of the DHEA produced per day can arise from DHEAS.