Pleiotropic signaling pathways in rapid, nongenomic action of glucocorticoid.
Pleiotropic signaling pathways in rapid, nongenomic action of glucocorticoid.
复制标题
DOI：
10.1006/mcbr.1999.0163
复制
发表时间：
1999-09-01
期刊：
影响因子：
--
通讯作者：
Qiu, J
中科院分区：
文献类型：
--
作者：
Chen, Y Z;Qiu, J
传统的类固醇作用的基因组理论不能完全解释激素类固醇的快速作用，并且认为由假定的膜受体介导的非基因组作用可能提供合理的解释。虽然有大量的证据证实类固醇激素的快速，非基因组效应，涉及的信号转导途径已被证明是复杂和多效性的。基于以往对糖皮质激素（GC）的快速、非基因组作用及其所涉及的G蛋白-蛋白激酶通路的研究，包括我们对PC 12、SK-N-SH、BT-325细胞和突触体的研究，本文将讨论GC快速、非基因组作用中涉及的多种信号转导通路的问题。
The traditional genomic theory of steroid action does not fully explain the rapid effects of hormonal steroids, and it is thought that the nongenomic actions mediated by a putative membrane receptor may provide a plausible explanation. Although there is a rich body of evidence to substantiate the rapid, nongenomic effects of steroid hormones, the signal transduction pathways involved have proved to be complex and pleiotropic. Based on previous studies on the rapid, nongenomic actions of glucocorticoid (GC) and the G-protein-protein kinase pathways involved, including our own studies on PC12, SK-N-SH, BT-325 cells, and synaptosomes, in this review we will discuss the issue of multiple signal transduction pathways involved in the rapid, nongenomic effects of GC.