PLASMODIUM-BERGHEI - QUANTITATION OF SPOROZOITES INJECTED BY MOSQUITOS FEEDING ON A RODENT HOST
PLASMODIUM-BERGHEI - QUANTITATION OF SPOROZOITES INJECTED BY MOSQUITOS FEEDING ON A RODENT HOST
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DOI：
10.1016/0014-4894(77)90075-3
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发表时间：
1977-01-01
影响因子：
2.1
通讯作者：
VANDERBERG, JP
中科院分区：
文献类型：
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作者：
VANDERBERG, JP
尝试确定以啮齿动物宿主（小鼠、大鼠、仓鼠）为食的史氏按蚊所注射的活伯氏疟原虫子孢子的数量。通过计算已知数量的受感染蚊子产生的红细胞外形式的数量来评估注射的数量。结果显示，注射的活子孢子数量非常少，约为唾液腺中子孢子总数的1%左右。唾液腺中含有大量子孢子的蚊子会注射更多的子孢子。严重感染的蚊子可能是更有效的媒介。蚊子注射的子孢子的相对数量随着所捕食的宿主的不同而变化。因此，推测宿主皮肤因素可能是感染性子孢子沉积在皮肤后能够到达血液的数量的重要决定因素。
Attempts were made to determine the numbers of viable P. berghei sporozoites injected by Anopheles stephensi mosquitoes feedong on rodent hosts [mice, rats, hamsters]. Assessment of the numbers injected was made by counting the numbers of exoerythrocytic forms produced by known numbers of infected mosquitoes. The results showed the numbers of viable sporozoites injected to be quite small, on the order of about 1% of the total number of sporozoites in the salivary glands. Mosquitoes with larger numbers of sporozoites in their salivary glands injected more sporozoites. Heavily infected mosquitoes may be more effective vectors. The relative numbers of sporozoites injected by the mosquitoes varied with the host being fed upon. Because of this, it is speculated that host skin factors may be an important determinant of the number of infective sporozoites able to reach the blood after being deposited in the skin.