Antimicrobial activity of mucosal-associated invariant T cells
Antimicrobial activity of mucosal-associated invariant T cells
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DOI：
10.1038/ni.1890
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发表时间：
2010-08-01
影响因子：
30.5
通讯作者：
Lantz, Olivier
中科院分区：
文献类型：
--
作者：
Le Bourhis, Lionel;Martin, Emmanuel;Lantz, Olivier
粘膜相关不变T淋巴细胞（MAIT淋巴细胞）的特征在于两个进化上保守的特征：不变的T细胞抗原受体（TCR）α链和主要组织相容性复合体（MHC）相关蛋白MR1的限制。在这里，我们表明，MAIT细胞被激活的细胞感染各种菌株的细菌和酵母，但不是细胞感染病毒，在人类和小鼠。这种激活需要恒定TCR和MR 1之间的同源相互作用，MR 1可以呈递细菌衍生的配体。在人类中，我们观察到患有细菌感染（如结核病）的患者血液中的MAIT细胞相当少。在小鼠中，MAIT细胞保护免受结核分枝杆菌或大肠杆菌的感染。因此，MAIT细胞是进化上保守的先天性淋巴细胞样细胞，可以感知并帮助抵抗微生物感染。
Mucosal-associated invariant T lymphocytes (MAIT lymphocytes) are characterized by two evolutionarily conserved features: an invariant T cell antigen receptor (TCR)alpha-chain and restriction by the major histocompatibility complex (MHC)-related protein MR1. Here we show that MAIT cells were activated by cells infected with various strains of bacteria and yeast, but not cells infected with virus, in both humans and mice. This activation required cognate interaction between the invariant TCR and MR1, which can present a bacteria-derived ligand. In humans, we observed considerably fewer MAIT cells in blood from patients with bacterial infections such as tuberculosis. In the mouse, MAIT cells protected against infection by Mycobacterium abscessus or Escherichia coli. Thus, MAIT cells are evolutionarily conserved innate-like lymphocytes that sense and help fight off microbial infection.