Attention influences single unit and local field potential response latencies in visual cortical area V4.
Attention influences single unit and local field potential response latencies in visual cortical area V4.
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DOI：
10.1523/jneurosci.0489-12.2012
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发表时间：
2012-11-07
期刊：
影响因子：
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通讯作者：
Reynolds JH
中科院分区：
文献类型：
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作者：
Sundberg KA;Mitchell JF;Gawne TJ;Reynolds JH
许多研究表明，选择性注意的改变可以改变视觉皮层神经元的反应幅度，但很少有证据表明注意影响反应潜伏期。微小的延迟差异，虽然很难检测到，但可能具有潜在的功能重要性，并且也可以深入了解神经元计算的机制。因此，我们重新研究了注意力对灵长类动物视觉皮质V4区单单元反应潜伏期和局部场电位（LFP）的影响。我们发现，注意确实会对尖峰反应和LFP反应的延迟产生很小的（1-2毫秒）但显著的减少。虽然注意，如对比度提升，减少反应延迟，我们发现两者对LFP的大小有不同的影响。对比升高会使刺激诱发的LFP的初始偏转幅度增大，而注意会使LFP的初始偏转幅度减小。对比度提升和注意力都增加了尖峰反应的幅度。我们推测，在高对比度下，潜伏期可能会减少，因为更强的刺激输入会使神经元更快地达到峰值阈值，而注意力可能会通过在刺激开始前将神经元置于更接近阈值的去极化状态来减少潜伏期。
Many previous studies have demonstrated that changes in selective attention can alter the response magnitude of visual cortical neurons, but there has been little evidence for attention affecting response latency. Small latency differences, though hard to detect, can potentially be of functional importance, and may also give insight into the mechanisms of neuronal computation. We therefore re-examined the effect of attention on the response latency of both single units and the local field potential (LFP) in primate visual cortical area V4. We find that attention does produce small (1–2 msec) but significant reductions in the latency of both the spiking and LFP responses. Though attention, like contrast elevation, reduces response latencies, we find that the two have different effects on the magnitude of the LFP. Contrast elevations increase and attention decreases the magnitude of the initial deflection of the stimulus-evoked LFP. Both contrast elevation and attention increase the magnitude of the spiking response. We speculate that latencies may be reduced at higher contrast because stronger stimulus inputs drive neurons more rapidly to spiking threshold, while attention may reduce latencies by placing neurons in a more depolarized state closer to threshold prior to stimulus onset.