METABOLITIES OF THE MARINE PROSOBRANCH MOLLUSK LAMELLARIA SP
METABOLITIES OF THE MARINE PROSOBRANCH MOLLUSK LAMELLARIA SP
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DOI：
10.1021/ja00305a027
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发表时间：
1985-01-01
影响因子：
15
通讯作者：
CLARDY, J
中科院分区：
文献类型：
--
作者：
ANDERSEN, RJ;FAULKNER, DJ;CLARDY, J
海洋前鳃类软体动物Lamellaria sp.含有4种芳香族代谢产物，即lamellarins A-D（1-4）。通过X射线晶体学研究确定了片螺素A（1）的结构，并通过光谱数据的解释指定了片螺素B-D（2-4）的结构。层状A（1）在溶液中以两种几何异构体的1：1混合物存在，这是由于围绕C1-C11键的旋转受限。分子力学计算表明，旋转势垒很大（> 600千卡/摩尔）。
The marine prosobranch mollusc, Lamellaria sp. contains four aromatic metabolies, lamellarins A-D (1-4). The structure of lamellarin A (1) was determined by an X-ray crystallographic study and the structures of lamellarins B-D (2-4) were assigned by interpretation of spectral data. Lamellarian A (1) exists in solution as a 1:1 mixture of two geometrical isomers due to restricted rotation about the C1-C11 bond. Molecular mechanics calculations revealed that the barrier to rotation was large (> 600 kcal/mol).