Vulnerable Caregivers of Alzheimer disease patients have a deficit in β2-adrenergic receptor sensitivity and density
Vulnerable Caregivers of Alzheimer disease patients have a deficit in β2-adrenergic receptor sensitivity and density
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DOI：
10.1176/appi.ajgp.12.3.281
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发表时间：
2004-05-01
影响因子：
7.2
通讯作者：
Grant, I
中科院分区：
文献类型：
--
作者：
Mills, PJ;Adler, KA;Grant, I
目的：慢性护理应激可导致交感神经系统激活和免疫抑制。β(2)-肾上腺素能受体在所有免疫细胞上表达，并导致应激诱导的免疫细胞功能丧失。作者研究了配偶照顾阿尔茨海默病患者（AD）对淋巴细胞β(2)-肾上腺素能受体的影响。方法：106名女性和男性，配偶照顾者和非照顾者，参与（平均年龄：71.5岁）。根据患者需要的护理量相对于护理人员在过去6个月内获得的喘息量，将护理人员分为易受伤害或非易受伤害两类。利用全淋巴细胞测定β(2)-肾上腺素能受体敏感性（异丙肾上腺素刺激的循环amp反应）和密度（放射性配体结合）。结果：与非弱势照顾者或非弱势照顾者相比，弱势照顾者的β(2)-肾上腺素能受体敏感性和密度降低。结论：研究结果表明，对于更脆弱的照顾者来说，照顾的压力导致淋巴细胞β(2)-肾上腺素能受体的丧失。这一发现可能与先前观察到的高压力照顾者临床相关的免疫力下降有关
Objective: The chronic stress of caregiving may lead to sympathetic nervous system activation and immune suppression. beta(2)-adrenergic receptors arc, expressed on all immune cells and contribute to the stress-induced loss of immune-cell function. The authors examined the effects of being a spousal caregiver of a patient with Alzheimer disease (AD) on the lymphocyte beta(2)-adrenergic receptor Methods: One hundred and six women and men, spousal caregivers and non-caregivers, participated (mean age: 71.5 years). Caregivers were classified as either vulnerable or non-vulnerable on the basis of the amount of care required by the patient relative to the amount of respite the caregiver received during the previous 6 months. beta(2)-adrenergic receptor sensitivity (cyclic-AMP response to isoproterenol stimulation) and density (radioligand binding) were determined by use of whole lymphocytes. Results: Vulnerable caregivers had reduced beta(2)-adrenergic receptor sensitivity and density when compared with their non-vulnerable counterparts or with non-caregivers. Conclusion: The findings indicate that for more vulnerable caregivers, the stress of caregiving leads to a loss of lymphocyte beta(2)-adrenergic receptors. This finding may be relevant to previous observations of clinically-relevant reduced immunity in highly stressed caregivers